INT213383

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Srd5a3, AR) nucleoplasm (AR) transport (AR)
endoplasmic reticulum (Srd5a3) enzyme binding (AR) DNA binding (AR)
Anatomy Link Frequency
TM4 2
Srd5a3 (Mus musculus)
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 85.72 High High
agonist 2 15.32 Low Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 99 88.32 High High
Prostate Cancer 19 81.44 Quite High
Apoptosis 14 64.60 Quite High
Fibrosis 2 5.00 Very Low Very Low Very Low
Carcinoma 2 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low
Fibrosarcoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the hAR-siRNA, which targets the human sequence but presents 5 mismatches out of 19 with the mouse mRNA, inhibits AR expression in LNCaP but not in mouse TM4 cells (Figure 1A).
hAR Negative_regulation (inhibits) of Gene_expression (expression) of AR in TM4
1) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.70 Pain Relevance 0.04

General Comments

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