INT213406

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XPO1) nuclear envelope (XPO1) cytoplasm (XPO1)
cytosol (XPO1) protein transporter activity (XPO1) RNA binding (XPO1)
Anatomy Link Frequency
liver 1
satellite cell 1
muscle 1
Knee 1
XPO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 80.64 Quite High
Pain 4 38.56 Quite Low
tolerance 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 16 99.96 Very High Very High Very High
Malaria 80 99.08 Very High Very High Very High
Disorder Of Lipid Metabolism 44 89.16 High High
Hypercalcemia 4 86.48 High High
Stress 48 84.92 Quite High
INFLAMMATION 32 80.64 Quite High
Metabolic Syndrome 20 73.88 Quite High
Disease 4 66.56 Quite High
Aging 28 54.08 Quite High
Injury 8 45.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests.
Neg (no) Positive_regulation (increased) of CrM in liver associated with disorders of creatine metabolism
1) Confidence 0.27 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1994592 Disease Relevance 0.41 Pain Relevance 0.04
We have also previously reported that older adults show a significant increase in total muscle creatine following four months of CrM supplementation at the same dose as used in the current study [15].
Positive_regulation (increase) of CrM in muscle
2) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.40 Pain Relevance 0.04
The molecular mechanism(s) behind the observed enhancement of the FFM with CrM were not evaluated in the current study and may have included an increase in satellite cell recruitment [17], [19], lower protein breakdown and oxidation [20], or increased myofibrillar protein accretion [21].
Positive_regulation (enhancement) of CrM in satellite cell
3) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0 Pain Relevance 0
Knee extension strength was the only strength outcome that showed a sex difference with greater increases for women on CrM+CLA after training compared to all other groups.
Positive_regulation (increases) of CrM in Knee
4) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0 Pain Relevance 0
Following the report that the isotype distribution of antimalarial antibodies was a critical parameter of malaria immunity [46], various studies confirmed the increase of IgG3 with age, and hence with protection, for many malarial antigens including SIRBC extract, MSP1, MSP2, AMA1, RESA, GLURP, p126-SERP-SERA, EBA 175, TRAP, and Exp1 [28,38,39,45,52,55–62].
Positive_regulation (increase) of Exp1 associated with malaria
5) Confidence 0.07 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.39 Pain Relevance 0

General Comments

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