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Context Info
Confidence 0.21
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
spinal cord 2
striatum 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 51 100.00 Very High Very High Very High
Spinal cord 27 100.00 Very High Very High Very High
opioid receptor 25 98.16 Very High Very High Very High
primary somatosensory cortex 56 97.76 Very High Very High Very High
Anterior cingulate cortex 67 96.44 Very High Very High Very High
Morphine 88 94.56 High High
GABAergic 13 91.16 High High
Inflammation 5 89.76 High High
gABA 6 79.64 Quite High
Dorsal horn 12 77.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 129 98.00 Very High Very High Very High
Aids-related Complex 131 95.44 Very High Very High Very High
INFLAMMATION 5 89.76 High High
Nociception 71 84.24 Quite High
Urological Neuroanatomy 2 57.84 Quite High
Generalized Anxiety Disorder 1 56.72 Quite High
Pain 39 50.08 Quite High
Nervous System Injury 6 43.60 Quite Low
Neuropathic Pain 7 42.40 Quite Low
Inflammatory Pain 4 37.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to assess changes in enkephalin release and biosynthesis, the levels of the tripeptide Tyr-Gly-Gly (YGG), a characteristic extracellular metabolite of enkephalins, and of the proenkephalin mRNA in mouse striatum were evaluated after a single administration of GABAergic agents.
Regulation (changes) of Localization (release) of enkephalin in striatum associated with gabaergic and enkephalin
1) Confidence 0.21 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.45
It is unlikely that these enhancements are due to the endogenous release of enkephalin because the deficiency of enkephalin in fiber terminals was demonstrated for KO mice.
Regulation (due) of Localization (release) of enkephalin associated with targeted disruption and enkephalin
2) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.64 Pain Relevance 1.42
Preproenkephalin mRNA is the precursor of both Met- and Leu-enkephalin, which are both expressed by neurons in the spinal cord and mainly exert their effect on the ?
Regulation (exert) of Localization (precursor) of enkephalin in spinal cord associated with enkephalin and spinal cord
3) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.74 Pain Relevance 0.96

General Comments

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