INT213431

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 9.91
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
livers 4
macrophages 2
cartilage 2
fibroblasts 2
ECM 2
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 76 100.00 Very High Very High Very High
Inflammation 226 98.94 Very High Very High Very High
cytokine 192 98.68 Very High Very High Very High
chemokine 44 98.24 Very High Very High Very High
Pain 14 95.36 Very High Very High Very High
Chronic pancreatitis 132 94.08 High High
Osteoarthritis 35 81.20 Quite High
fibrosis 78 77.24 Quite High
sodium channel 5 75.84 Quite High
Inflammatory response 31 72.96 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 100 100.00 Very High Very High Very High
Adhesions 93 100.00 Very High Very High Very High
Hyperplasia 6 99.96 Very High Very High Very High
Fibrosis 166 99.84 Very High Very High Very High
Glaucoma 91 99.60 Very High Very High Very High
Uterine Fibroids 120 99.56 Very High Very High Very High
Primary Sclerosing Cholangitis 308 99.48 Very High Very High Very High
Cirrhosis 123 99.32 Very High Very High Very High
INFLAMMATION 260 98.94 Very High Very High Very High
Stress 237 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The collagen sponge, in contrast, is easily manipulated, does not require use of specialized chondrogenic media to allow ECM production, provides ample room for meniscal cell expansion and ECM production, and is easily embedded for morphologic studies.


Neg (not) Positive_regulation (require) of Gene_expression (production) of ECM
1) Confidence 0.24 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.27 Pain Relevance 0.07
The collagen sponge, in contrast, is easily manipulated, does not require use of specialized chondrogenic media to allow ECM production, provides ample room for meniscal cell expansion and ECM production, and is easily embedded for morphologic studies.


Neg (not) Positive_regulation (provides) of Gene_expression (production) of ECM
2) Confidence 0.24 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.29 Pain Relevance 0.07
In vitro increase of ECM production is induced by PBMC
Positive_regulation (increase) of Gene_expression (production) of ECM
3) Confidence 0.20 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.77 Pain Relevance 0.09
Furthermore, it has been shown that LPS-activated macrophages stimulate the synthesis of ECM proteins by PSC [21].
Positive_regulation (stimulate) of Gene_expression (synthesis) of ECM in macrophages associated with primary sclerosing cholangitis
4) Confidence 0.17 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.76 Pain Relevance 0.39
PSC have been determined as the major source of ECM protein production, and have also been shown to produce cytokines and chemokines [7-11].
Spec (determined) Positive_regulation (source) of Spec (determined) Gene_expression (source) of ECM protein associated with chemokine, primary sclerosing cholangitis and cytokine
5) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.49 Pain Relevance 0.56
In vitro increase of ECM production is induced by PBMC
Positive_regulation (induced) of Gene_expression (production) of ECM
6) Confidence 0.14 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.77 Pain Relevance 0.09
Leiomyomas are characterized by excessive collagen production in the ECM.7,16 We therefore evaluated the effect of ATRA treatment on collagen production in leiomyoma cell cultures by measuring salt soluble collagen secreted into the media after 24 h of ATRA treatment, prior to one cycle of cell division.
Positive_regulation (excessive) of Gene_expression (production) of ECM associated with uterine fibroids
7) Confidence 0.09 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.95 Pain Relevance 0
pathway, which affects differentiation, proliferation, migration, and the induction of extracellular matrix (ECM) production, as well as genes responsible for ECM biosynthesis and modification [27–30].
Positive_regulation (induction) of in extracellular matrix Gene_expression (production) of ECM in ECM
8) Confidence 0.09 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.31 Pain Relevance 0.10
The overall take-home message from these early studies was clear: ROS, mainly H2O2, HNE and HAKs of different chain length, released in a paracrine way by damaged hepatocytes, endothelial cells or activated inflammatory cells, can easily cross the membrane of HSC/MFs and lead to increased synthesis of pro-collagen type I, a significant component of the fibrillar-like ECM in fibrotic and cirrhotic livers.


Positive_regulation (lead) of Gene_expression (synthesis) of fibrillar-like ECM in livers associated with fibrosis, cirrhosis and inflammation
9) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0.05
The overall take-home message from these early studies was clear: ROS, mainly H2O2, HNE and HAKs of different chain length, released in a paracrine way by damaged hepatocytes, endothelial cells or activated inflammatory cells, can easily cross the membrane of HSC/MFs and lead to increased synthesis of pro-collagen type I, a significant component of the fibrillar-like ECM in fibrotic and cirrhotic livers.


Positive_regulation (increased) of Gene_expression (synthesis) of fibrillar-like ECM in livers associated with fibrosis, cirrhosis and inflammation
10) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0.05
According to a previous study on rat lung fibroblasts [30], we found that the functional inhibition of ECM contraction by human joint capsule MFs upon TNF-?
Positive_regulation (upon) of Gene_expression (contraction) of ECM in lung
11) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.14 Pain Relevance 0.12
stimulates cellular proliferation, induces production of ECM and inhibits phagocytosis of collagen by gingival fibroblasts [68,69].
Positive_regulation (induces) of Gene_expression (production) of ECM in fibroblasts associated with hyperplasia
12) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.10 Pain Relevance 0.10
The 10-7 M adrenomedullin significantly enhanced RA-FLS adhesion to all three ECM proteins (Figure 1a), with a 2.39-, 2.25-, and 1.65-fold increase for vitronectin, fibronectin, and Coll.I, respectively (all with P < 0.0001).
Positive_regulation (enhanced) of Gene_expression (adhesion) of ECM associated with rheumatoid arthritis and adhesions
13) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.85 Pain Relevance 0.13
The early chronic phase (2–3 weeks) was associated with increased expression of ECM related proteases (ie, MMP-12), cytokines, chemokines, and stress response proteins.
Positive_regulation (increased) of Gene_expression (expression) of ECM associated with stress, chemokine and cytokine
14) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 0.70 Pain Relevance 0.13
Our findings show that glaucoma is associated with increased expression of genes that mediate axonal outgrowth, immune response, cell motility, neuroprotection, and ECM remodeling.
Positive_regulation (increased) of Gene_expression (expression) of ECM associated with glaucoma
15) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2567987 Disease Relevance 0.50 Pain Relevance 0
While FGF2 has already been found to substantially increase cell proliferation in bovine spine discs [52], it failed to increase ECM synthesis in parallel in our study, resulting in clustering of cells with little surrounding ECM – a hallmark of arthritic cartilage.
Neg (failed) Positive_regulation (increase) of Gene_expression (synthesis) of ECM in cartilage associated with arthritis
16) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0.16 Pain Relevance 0

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