INT213442

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.30
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXCL3) extracellular region (CXCL3)
Anatomy Link Frequency
Macrophage 1
immune cells 1
esophagus 1
CXCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 123 100.00 Very High Very High Very High
chemokine 83 100.00 Very High Very High Very High
cytokine 24 100.00 Very High Very High Very High
metalloproteinase 5 100.00 Very High Very High Very High
rheumatoid arthritis 49 92.08 High High
palliative 1 39.48 Quite Low
Inflammatory response 7 15.80 Low Low
cINOD 6 9.88 Low Low
COX2 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 134 100.00 Very High Very High Very High
Down Syndrome 4 100.00 Very High Very High Very High
Periodontitis 32 99.42 Very High Very High Very High
Cancer 185 98.92 Very High Very High Very High
Metastasis 27 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 3 98.72 Very High Very High Very High
Recurrence 29 98.64 Very High Very High Very High
Polyps 29 98.56 Very High Very High Very High
Infection 4 98.56 Very High Very High Very High
Apoptosis 21 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, IL-8, CXCL1, CXCL2, CXCL3, and CCL20 had higher levels of expression in the polyps compared to normal, which is in keeping with the current study.
Gene_expression (had) of CXCL3 associated with polyps
1) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.29 Pain Relevance 0.26
The disparity in angiogenic activity among CXC chemokine family members is attributed to three amino acid structural domains at the N terminus, Glu-Leu-Arg (ELR), which is present in angiogenic (i.e., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8) [4-6], but not angiostatic (i.e., CXCL4, CXCL9, CXCL10, and CXCL11) CXC chemokines [7].
Gene_expression (present) of CXCL3 associated with chemokine
2) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.65 Pain Relevance 0.27
Arterial SMCs, in particular, express a large set of genes that mediate these interactions—such as cytokines/chemokines (IL6, CCL8, CCL7, CCL2, CXCL1, CXCL2, CXCL3, and CXCL6), complement pathway (complement factor B [CFB]), and surface receptor (ICAM1) (Figure 3B)—suggesting that vascular SMCs may themselves mediate recruitment of immune cells to the vascular walls.
Gene_expression (express) of CXCL3 in immune cells associated with chemokine and cytokine
3) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.17 Pain Relevance 0.10
This conclusion is supported, at least in part, by the results of Sukumaran and colleagues [52], who reported the upregulated expression of chemokine genes encoding CXCL1, CXCL2, CXCL3, CXCL8, CCL3, CCL4 and CCL20 after infection of PMN with Anaplasma phagocytophilum.
Gene_expression (expression) of CXCL3 associated with chemokine and infection
4) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.59 Pain Relevance 0.50
Recently, overexpression of CXCL3 has been observed in many cancers, including esophagus cancer31 and breast cancer,32 and has been suggested as being related to cancer recurrence.
Gene_expression (overexpression) of CXCL3 in esophagus associated with cancer, breast cancer and recurrence
5) Confidence 0.24 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.07 Pain Relevance 0.05
However, Li et al reported that CXCL3 expression had no relation with remote metastasis of CRC,33 which means CXCL3 may have a different function in CRC.
Gene_expression (expression) of CXCL3 associated with colon cancer and metastasis
6) Confidence 0.24 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.20 Pain Relevance 0.04
CXCL-3 expression has been described to drastically increase after inoculation of Porphyromonas gingivalis in rats immunized against P. gingivalis [30].
Gene_expression (expression) of CXCL-3
7) Confidence 0.08 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.48 Pain Relevance 0.03
In gingival tissues from treated periodontitis sites, the 5% most strongly expressed genes were Interleukin-12A (IL-12A, NM_000882, 3.1-fold), Versican (CSPG-2, NM_004385, 3.35-fold), Matrix metalloproteinase-1 (MMP-1, NM_002421, 3.37-fold), Down syndrome critical region protein-1 (DSCR-1, NM_004414, 3.79-fold), Macrophage inflammatory protein-2beta (cxcl-3, NM_002090, 3.99-fold), Inhibitor of apoptosis protein-1 (BIRC-1, NM_004536, 4.04-fold), Cluster of differentiation antigen 38 (CD38, NM_001775, 4.43-fold), Regulator of G-protein signalling-1 (RGS-1, NM_002922, 5.53-fold), and Finkel-Biskis-Jinkins murine osteosarcoma virus oncogene (C-FOS, NM_005252, 5.65-fold).
Gene_expression (expressed) of cxcl-3 in Macrophage associated with down syndrome, periodontitis, inflammation, metalloproteinase, osteogenic sarcomas and apoptosis
8) Confidence 0.05 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.85 Pain Relevance 0.16

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