INT213447

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.98
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (APOLD1) lipid binding (APOLD1) extracellular region (APOLD1)
plasma membrane (APOLD1)
Anatomy Link Frequency
visceral 1
blood vessel 1
APOLD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 6 85.88 High High
Inflammation 12 82.60 Quite High
Inflammatory response 9 5.40 Low Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 57 100.00 Very High Very High Very High
Atherosclerosis 27 99.40 Very High Very High Very High
Ovarian Cancer 9 91.16 High High
Necrosis 3 83.24 Quite High
Cancer 108 82.88 Quite High
INFLAMMATION 21 82.60 Quite High
Congenital Anomalies 15 46.72 Quite Low
Microphthalmia 3 36.24 Quite Low
Increased Venous Pressure Under Development 9 14.48 Low Low
Breast Cancer 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, hypoxia of the blood vessel wall has been linked to the development of atherosclerosis [37,38], so the differential expression of this hypoxia-response gene set and its influence on the transcriptional program under low oxygen tension may have implications for the pathogenesis of atherosclerosis.


Gene_expression (expression) of hypoxia-response gene in blood vessel associated with atherosclerosis and hypoxia
1) Confidence 0.09 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.12 Pain Relevance 0.05
To test whether an expression signature of the hypoxia response was indeed overrepresented in vascular SMCs, we used a previously obtained hypoxia-response gene signature [36] to analyze the SMC expression dataset.
Spec (analyze) Gene_expression (expression) of hypoxia-response gene associated with hypoxia
2) Confidence 0.08 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.85 Pain Relevance 0.08
When all 60 SMC samples were arranged by hierarchical clustering based on the expression levels of all 71 genes in the common hypoxia-response gene list [36], most vascular SMCs clustered separately from visceral SMCs as a result of their relatively high expression of HIF1A and the common hypoxia-response genes (Figure 2D).
Gene_expression (expression) of hypoxia-response gene in visceral associated with hypoxia
3) Confidence 0.07 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.01 Pain Relevance 0.08

General Comments

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