INT213465

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.11
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
blood 1
fat 1
body 1
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 32 98.56 Very High Very High Very High
Hippocampus 10 98.20 Very High Very High Very High
methadone 78 96.88 Very High Very High Very High
addiction 2 70.72 Quite High
nMDA receptor 32 63.72 Quite High
long-term potentiation 17 63.44 Quite High
tolerance 14 19.92 Low Low
Abstinence syndrome 6 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 78 98.68 Very High Very High Very High
Obesity 170 98.08 Very High Very High Very High
Targeted Disruption 13 89.12 High High
Diabetes Mellitus 31 78.68 Quite High
Weight Gain 4 77.96 Quite High
Opiate Addiction 4 71.28 Quite High
Cognitive Disorder 4 44.72 Quite Low
Disorder Of Lipid Metabolism 13 37.16 Quite Low
Disease 4 32.16 Quite Low
Impaired Glucose Tolerance 10 20.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, in addition to crossing the blood–brain barrier, there is also evidence that leptin mRNA is expressed in a number of brain regions, including the hippocampus (Morash et al., 1999), suggesting that the actual concentration of leptin reaching hippocampal synapses may be derived from locally released leptin as well as leptin within the cerebrospinal fluid.
Transcription (expressed) of leptin in blood associated with hippocampus
1) Confidence 0.68 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.13 Pain Relevance 0.34
These results demonstrate that the perfused tissue maintains under in vitro condition the ability for de-novo synthesis of hCG and leptin.
Transcription (synthesis) of leptin
2) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2703629 Disease Relevance 0.07 Pain Relevance 0.81
Although leptin is produced only in adipose tissue and elicits satiety responses by binding to leptin receptors in the brain [89, 90], changes in leptin mRNA levels are in accordance with those in body weight and WAT mass in both female OVX and Sham mice following fenofibrate treatment.
Transcription (levels) of leptin in body associated with body weight and obesity
3) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.39 Pain Relevance 0
The same group studied mRNA expression of leptin and adiponectin in epididymal fat of 11?
Transcription (expression) of leptin in fat
4) Confidence 0.19 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.51 Pain Relevance 0

General Comments

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