INT213467

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
fat 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 32 84.16 Quite High
Hippocampus 10 67.04 Quite High
Glutamate 1 65.00 Quite High
tolerance 4 60.00 Quite High
tetrodotoxin 2 43.12 Quite Low
Action potential 2 40.76 Quite Low
long-term potentiation 17 39.20 Quite Low
depression 3 33.68 Quite Low
Eae 1 31.64 Quite Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 24 97.68 Very High Very High Very High
Weight Gain 3 89.84 High High
Targeted Disruption 14 89.00 High High
Obesity 47 87.44 High High
Diabetes Mellitus 5 82.24 Quite High
Cardiovascular Disease 1 79.04 Quite High
Disorder Of Lipid Metabolism 1 74.24 Quite High
Overweight 6 60.84 Quite High
Impaired Glucose Tolerance 4 60.64 Quite High
Depression 3 33.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M; 30 min) reversed the actions of leptin, such that in the presence of D-APV, leptin (50 nM; 30 min) significantly reduced the mean number of filopodia extending from dendritic processes to 1.35 ± 0.41 (n = 9; P < 0.05; Figs. 4B, D).
Negative_regulation (reduced) of Localization (presence) of leptin
1) Confidence 0.40 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.28
This normal regulation excludes a deficiency in leptin generation by fat tissue and therefore a reduced leptin-mediated control of food intake as being responsible for the fat accumulation in our NEP-deficient mice.
Negative_regulation (deficiency) of Localization (generation) of leptin in fat
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 1.11 Pain Relevance 0.03

General Comments

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