INT213471

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.65
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
adipose tissue 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 35 98.16 Very High Very High Very High
melanocortin 1 receptor 3 94.16 High High
tolerance 1 91.92 High High
adenocard 1 89.52 High High
Inflammation 58 83.04 Quite High
Inflammatory stimuli 6 77.28 Quite High
Inflammatory marker 4 67.76 Quite High
agonist 4 63.52 Quite High
Action potential 2 50.24 Quite High
tetrodotoxin 2 45.20 Quite Low
Disease Link Frequency Relevance Heat
Hypercapnia 10 99.58 Very High Very High Very High
Autoimmune Disease 4 99.58 Very High Very High Very High
Obesity 205 99.28 Very High Very High Very High
Infection 4 95.88 Very High Very High Very High
Disseminated Intravascular Coagulation 8 94.48 High High
Weight Gain 6 90.16 High High
INFLAMMATION 70 83.04 Quite High
Obesity-hypoventilation Syndrome 28 71.80 Quite High
Atherosclerosis 2 70.68 Quite High
Metabolic Syndrome 5 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of leptin (50 nM) resulted in a rapid (within 3–6 min) increase in both the number of filopodia extending from processes (mean density of 17.9 ±4.4; n = 16; P < 0.05) and the motility of these extensions (mean motility of 1.9 ± 0.26 ?
Positive_regulation (resulted) of Localization (Application) of leptin
1) Confidence 0.48 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.15 Pain Relevance 0.03
Conversely, immune-mediated disorders such as autoimmune diseases are associated with increased secretion of leptin and production of proinflammatory pathogenic cytokines.
Positive_regulation (increased) of Localization (secretion) of leptin associated with autoimmune disease and cytokine
2) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2846344 Disease Relevance 0.60 Pain Relevance 0.11
Leptin-deficient obese mice were observed to have a reduced ventilatory drive in response to hypercapnia, which subsequently improved on administration of leptin.43
Positive_regulation (improved) of Localization (administration) of leptin associated with hypercapnia and obesity
3) Confidence 0.38 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.36 Pain Relevance 0.05
Briefly, leptin is an endocrine hormone secreted in proportion to the amount of adipose tissue present.
Positive_regulation (proportion) of Localization (secreted) of leptin in adipose tissue associated with obesity
4) Confidence 0.15 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.53 Pain Relevance 0.55

General Comments

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