INT213475

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 1 79.36 Quite High
cytokine 25 56.60 Quite High
Inflammatory response 2 37.44 Quite Low
nMDA receptor 32 5.00 Very Low Very Low Very Low
long-term potentiation 17 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 40 99.84 Very High Very High Very High
Obesity 48 97.92 Very High Very High Very High
Targeted Disruption 5 93.92 High High
Stroke 1 92.80 High High
Heart Disease 1 92.48 High High
Starvation 2 84.80 Quite High
Necrosis 3 71.88 Quite High
Cancer 13 71.52 Quite High
Peripheral Arterial Disease 2 65.40 Quite High
Cardiovascular Disease 1 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of leptin (50 nM) occurred rapidly as a significant increase in filopodial density (to 206 ± 14% of control; mean density of 5.45 ± 0.36; n = 10; P < 0.01) was evident after 10 min incubation with leptin, with a peak increase (to 544 ± 95% of control; mean density of 13.8 ± 2.3; n = 12; P < 0.01) detected after 3 h exposure (Fig. 1D).
Spec (evident) Negative_regulation (evident) of Positive_regulation (incubation) of leptin
1) Confidence 0.40 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
At least, these alterations observed during fasting parallel the decrease in circulating leptin levels.
Negative_regulation (decrease) of Positive_regulation (circulating) of leptin
2) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.46 Pain Relevance 0.07
Harper et al., 2003 [36], observed a negative effect of high levels of serum leptin on lifespan.
Negative_regulation (effect) of Positive_regulation (levels) of serum leptin associated with lifespan
3) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693670 Disease Relevance 1.34 Pain Relevance 0

General Comments

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