INT21349

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Context Info
Confidence 0.07
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.90
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
neutrophils 2
platelet 1
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 65 97.68 Very High Very High Very High
antagonist 30 80.40 Quite High
peptic ulcer disease 1 79.88 Quite High
Inflammatory mediators 1 64.32 Quite High
fibrosis 3 44.88 Quite Low
cINOD 19 25.52 Quite Low
trigger zone 1 22.68 Low Low
COX-2 inhibitor 10 11.04 Low Low
corticosteroid 51 5.00 Very Low Very Low Very Low
cytokine 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 4 99.36 Very High Very High Very High
INFLAMMATION 67 97.68 Very High Very High Very High
Pulmonary Disease 107 97.00 Very High Very High Very High
Duodenal Ulcer 6 96.92 Very High Very High Very High
Leukemia 1 93.60 High High
Colon Cancer 5 92.00 High High
Apoptosis 44 90.28 High High
Asthma 88 85.28 High High
Disease 36 79.88 Quite High
Cancer 78 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTB4 interacts with the high-affinity BLT1 receptor expressed by immune/inflammatory cells, thus exerting a powerful chemoattractant effect particularly on neutrophils, but also on CD8+ T-cells (Martin et al 1989; Goodarzi et al 2003).
LTB4 Binding (interacts) of in neutrophils associated with inflammation
1) Confidence 0.07 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.93 Pain Relevance 0.23
Evidence also indicates that 15-S-HETE may have anti-tumorigenic effects by antagonizing other LOX products, such as LTB4 and 12-S-HETE [28]. 15-HETE inhibits LTB4 production and reduces LTB4 binding to its receptors and thereby blocks cellular responses to LTB4. 15-HETE also blocks platelet-type 12-LOX activity and reduces 5-LOX activity in rat basophilic leukemia cells [28,32].
LTB4 Binding (binding) of in platelet associated with leukemia
2) Confidence 0.03 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.76 Pain Relevance 0
Fundic LTB4 and LTC4 generation was similar in ulcer patients and controls.
LTB4 Binding (generation) of associated with ulcers
3) Confidence 0.02 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.85 Pain Relevance 0.08
The non-cysteinyl LT, LTB4, binds to the B leukotriene (BLT) receptor, which is responsible for recruitment and activation of leukocytes, in particular neutrophils (Yokomizo et al 1997; Devillier et al 1999a).
LTB4 Binding (binds) of in neutrophils
4) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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