INT2135

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Context Info
Confidence 0.44
First Reported 1978
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 2.17
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
liver 3
plasma 2
PGE1 1
blood vessels 1
muscle 1
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 41 100.00 Very High Very High Very High
Action potential 18 99.48 Very High Very High Very High
Inflammation 4 99.12 Very High Very High Very High
anesthesia 4 98.98 Very High Very High Very High
halothane 5 98.76 Very High Very High Very High
Gabapentin 2 98.24 Very High Very High Very High
Lamotrigine 2 97.16 Very High Very High Very High
action potential duration 4 77.20 Quite High
tetrodotoxin 6 77.12 Quite High
Glutamate 8 70.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.12 Very High Very High Very High
Apoptosis 1 98.44 Very High Very High Very High
Necrosis 3 98.00 Very High Very High Very High
Injury 29 97.64 Very High Very High Very High
Hepatotoxicity 19 94.64 High High
Toxicity 3 91.32 High High
Poisoning 9 71.04 Quite High
Liver Failure 1 63.76 Quite High
Death 1 62.28 Quite High
Hyperbilirubinemia 1 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of Goniopora toxin (GPT), a polypeptide isolated from a coral, Goniopora spp., on action potential and membrane currents were studied in single ventricular cells of the guinea-pig using the whole-cell clamp technique with a single patch electrode.
Regulation (effects) of GPT associated with action potential
1) Confidence 0.44 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2457173 Disease Relevance 0 Pain Relevance 0.24
The effects of Goniopora toxin (GPT), isolated from the coral Goniopora species, on the crayfish giant axon have been studied by means of microelectrode and sucrose-gap voltage clamp techniques.
Regulation (effects) of GPT
2) Confidence 0.40 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2410592 Disease Relevance 0 Pain Relevance 0.14
Effects of Goniopora toxin (GPT) on cardiac action potential and on contractile force were investigated in isolated guinea-pig papillary muscle.
Regulation (Effects) of GPT in papillary muscle associated with action potential
3) Confidence 0.39 Published 1981 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7334728 Disease Relevance 0 Pain Relevance 0.25
Effects of a marine polypeptide, Goniopora toxin (GPT) (molecular weight 12,000), were examined in isolated blood vessels guinea pigs.
Spec (examined) Regulation (Effects) of GPT in blood vessels
4) Confidence 0.35 Published 1980 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6250087 Disease Relevance 0 Pain Relevance 0.14
The effects of Goniopora toxin (GPT), isolated from the Goniopora species, on the action potential and membrane currents of bullfrog atrial muscle were studied using the double sucrose-gap method.
Regulation (effects) of GPT in muscle associated with action potential
5) Confidence 0.32 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6092970 Disease Relevance 0 Pain Relevance 0.15
In Vitro antioxidative activity of pumpkin seed (Cucurbita pepo) protein isolate and its In Vivo effect on alanine transaminase and aspartate transaminase in acetaminophen-induced liver injury in low protein fed rats.
Regulation (effect) of alanine transaminase in liver associated with paracetamol and injury
6) Confidence 0.31 Published 2006 Journal Phytother Res Section Title Doc Link 16807884 Disease Relevance 0.30 Pain Relevance 0.30
Subsequently the effects of the isolate on the plasma activity levels of alanine transaminase and aspartate transaminase against acetaminophen induced acute liver injury in low-protein fed male Sprague-Dawley rats were ascertained.
Regulation (effects) of alanine transaminase in liver associated with paracetamol and injury
7) Confidence 0.31 Published 2006 Journal Phytother Res Section Abstract Doc Link 16807884 Disease Relevance 0.24 Pain Relevance 0.25
The effects of halothane anesthesia on liver function, as reflected by postanesthetic changes in serum glutamic pyruvic transaminase (SGPT) levels, were evaluated in 2 groups of 40 patients.
Regulation (changes) of serum glutamic pyruvic transaminase in liver associated with anesthesia and halothane
8) Confidence 0.27 Published 1978 Journal Anesth. Analg. Section Abstract Doc Link 360877 Disease Relevance 0 Pain Relevance 0.31
It completely antagonized the toxic effects of paracetamol on certain enzymes (GOT, GPT and alkaline phosphatase) in serum as well as in isolated hepatic cells.
Regulation (effects) of GPT associated with paracetamol
9) Confidence 0.27 Published 1993 Journal J Ethnopharmacol Section Abstract Doc Link 8133653 Disease Relevance 0.09 Pain Relevance 0.27
Their effect on the body and organs weight and certain biochemical profiles including total serum protein, cholesterol, triglycerides, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum testosterone, and FSH levels were also measured.
Regulation (effect) of serum glutamic pyruvic transaminase in body
10) Confidence 0.22 Published 2004 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 15349082 Disease Relevance 0 Pain Relevance 0.26
This protective effect was not observed in rats fed a low protein diet and manifested in the concentrations of GPT and GOT in plasma and GSH levels in liver.
Regulation (concentrations) of GPT in plasma
11) Confidence 0.21 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.17 Pain Relevance 0.26
The same dose of plant extract (500 mg/kg) was able to significantly prevent (P < 0.05) CCl4-induced rise in serum enzymes and the estimated values of ALP, GOT and GPT were 220 +/- 30, 207 +/- 95 and 75 +/- 38, respectively. 7.
Regulation (values) of GPT
12) Confidence 0.17 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.20 Pain Relevance 0.32
The levels of plasma alanine transaminase (ALT) and aspartate transaminase (AST) were determined for each group after treatment.
Spec (determined) Regulation (determined) of plasma alanine transaminase in plasma
13) Confidence 0.10 Published 2004 Journal Chin. Med. J. Section Body Doc Link 14975216 Disease Relevance 0.07 Pain Relevance 0
Matching changes in serum alanine transaminase (ALT), aspartate transaminase (AST) and cyt c peaked at 24 h for either drug at the highest dose, cyt c falling rapidly at 48 hours with ALT and AST remained high.
Regulation (changes) of serum alanine transaminase
14) Confidence 0.02 Published 2008 Journal J Appl Toxicol Section Abstract Doc Link 18418843 Disease Relevance 0.63 Pain Relevance 0.14
Change of serum GOT, GPT, albumin, total bilirubin, and cholinesterase (ChE) showed no difference between the patients with and without PGE1 administration in groups B and C.
Regulation (Change) of GPT in PGE1
15) Confidence 0.02 Published 1994 Journal Masui Section Abstract Doc Link 8072150 Disease Relevance 0.47 Pain Relevance 0

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