INT21350

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.77
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
plasma 2
neutrophil 2
paw 1
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 1 100.00 Very High Very High Very High
Pain threshold 1 99.84 Very High Very High Very High
corticosteroid 40 99.82 Very High Very High Very High
Cluster headache 8 99.56 Very High Very High Very High
Intracerebroventricular 3 99.36 Very High Very High Very High
Inflammation 98 99.26 Very High Very High Very High
Bioavailability 1 95.76 Very High Very High Very High
cINOD 8 95.20 Very High Very High Very High
Inflammatory mediators 14 94.72 High High
Hyperalgesia 1 92.84 High High
Disease Link Frequency Relevance Heat
Ulcers 4 100.00 Very High Very High Very High
Occupational Lung Diseases 163 99.84 Very High Very High Very High
Pain 2 99.84 Very High Very High Very High
Cluster Headache 8 99.56 Very High Very High Very High
INFLAMMATION 115 99.26 Very High Very High Very High
Adenoma 1 99.20 Very High Very High Very High
Asthma 90 93.44 High High
Duodenal Ulcer 6 93.36 High High
Hyperalgesia 2 92.84 High High
Cancer 3 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of LTB4 and 12-HETE was measured using a single LTB4 RIA, following extraction and separation of these eicosanoids from plasma.
Negative_regulation (Inhibition) of LTB4 in plasma
1) Confidence 0.33 Published 1988 Journal J Pharmacol Methods Section Abstract Doc Link 3145369 Disease Relevance 0 Pain Relevance 0.40
A significant reduction in exhaled LTB4 levels was observed only in the group of children who were receiving 200 ?
Negative_regulation (reduction) of LTB4
2) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 1.14 Pain Relevance 0.10
These findings might indicate that the lower dose of fluticasone is unable to reduce exhaled LTB4 levels in asthmatic children.
Neg (unable) Negative_regulation (reduce) of LTB4 associated with occupational lung diseases
3) Confidence 0.17 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0.90 Pain Relevance 0.06
Although placebo control studies are warranted, inhaled corticosteroids seem to reduce exhaled LTB4 in asthmatic children.
Negative_regulation (reduce) of LTB4 associated with corticosteroid and occupational lung diseases
4) Confidence 0.17 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1283153 Disease Relevance 0.71 Pain Relevance 0.13
Altogether, the results suggest that SGE has anti-inflammatory properties that are associated with inhibition of TNF-alpha and LTB4 production and/or with the neutrophil chemotactic activity of LTB4.
Negative_regulation (inhibition) of LTB4 in neutrophil associated with inflammation
5) Confidence 0.17 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.50 Pain Relevance 0.22
NNK suppressed humoral and cellular immune responses and increased plasma PGE2 and LTB4 levels.
Negative_regulation (suppressed) of LTB4 in plasma
6) Confidence 0.08 Published 1998 Journal Exp. Lung Res. Section Abstract Doc Link 9659586 Disease Relevance 0.19 Pain Relevance 0.16
Altogether, the results suggest that SGE has anti-inflammatory properties that are associated with inhibition of TNF-alpha and LTB4 production and/or with the neutrophil chemotactic activity of LTB4.
Negative_regulation (inhibition) of LTB4 in neutrophil associated with inflammation
7) Confidence 0.07 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.49 Pain Relevance 0.21
This compound was effective on PGE2, LTB4, bradykinin, PAF or IL-1 beta-induced decrease in pain threshold in the rat paw pressure model and almost totally suppressed the writhing induced by zymosan in mice, while peritoneal production of 6-ketoPGF1 alpha was inhibited by 48.5-62% and only at 100 mg/kg significant inhibition of LTC4 was achieved.
Negative_regulation (decrease) of LTB4 in paw associated with pain threshold and bradykinin
8) Confidence 0.07 Published 1995 Journal Life Sci. Section Abstract Doc Link 7564876 Disease Relevance 0.54 Pain Relevance 0.58
Vehicle, LTB4 or U75302 (a selective LTB4 BLT1 receptor inhibitor) was given via intracerebroventricular injection (i.c.v.) 30 min before challenge.
Negative_regulation (inhibitor) of BLT1 associated with intracerebroventricular
9) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2834663 Disease Relevance 0.71 Pain Relevance 0.28
A reduction of LTC4 and LTB4 levels in CH patients was also observed in R-P HPLC, which showed different elution patterns in the two groups.
Negative_regulation (reduction) of LTB4 associated with cluster headache
10) Confidence 0.03 Published 1989 Journal Headache Section Abstract Doc Link 2466813 Disease Relevance 0.73 Pain Relevance 0.66
In 11 patients PAF, LTB4, and LTC4 generation was also assessed after 4 weeks of treatment resulting in ulcer healing and found to be significantly reduced when compared with their synthesis when the ulcer was active.
Negative_regulation (reduced) of LTB4 associated with ulcers
11) Confidence 0.01 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.85 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox