INT213501

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.74
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Defa1) extracellular region (Defa1)
Anatomy Link Frequency
intestines 2
Defa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 148 99.96 Very High Very High Very High
Inflammation 114 98.24 Very High Very High Very High
cytokine 6 82.00 Quite High
corticosteroid 29 28.56 Quite Low
potassium channel 2 6.80 Low Low
Bile 12 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 182 99.96 Very High Very High Very High
Inflammatory Bowel Disease 274 99.84 Very High Very High Very High
INFLAMMATION 94 98.24 Very High Very High Very High
Infection 22 87.28 High High
Sprains And Strains 6 74.32 Quite High
Celiac Disease 4 28.44 Quite Low
Colitis 19 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 14 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Canker Sores 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease.
Negative_regulation (impaired) of Gene_expression (production) of defensin in intestines associated with crohn's disease and disease
1) Confidence 0.42 Published 2010 Journal International Journal of Inflammation Section Abstract Doc Link PMC2992817 Disease Relevance 0.45 Pain Relevance 0.18
Therefore, probiotics such as E.coli Nissle 1917 can reverse the decrease in defensin expression in UC, but not in CD.
Neg (not) Negative_regulation (reverse) of Gene_expression (expression) of defensin associated with inflammatory bowel disease and crohn's disease
2) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.20 Pain Relevance 0.17
Therefore, probiotics such as E.coli Nissle 1917 can reverse the decrease in defensin expression in UC, but not in CD.
Negative_regulation (decrease) of Gene_expression (expression) of defensin associated with inflammatory bowel disease and crohn's disease
3) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.20 Pain Relevance 0.17
In UC, defensins are reversibly down-regulated for unknown reasons, whereas in CD, defensin expression is permanently impaired because of genetic alterations.
Negative_regulation (impaired) of Gene_expression (expression) of defensin associated with inflammatory bowel disease and crohn's disease
4) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.20 Pain Relevance 0.16
These findings challenge the perspective that reduced defensin expression is merely the result of epithelial loss in inflammatory states [77].
Negative_regulation (reduced) of Gene_expression (expression) of defensin associated with inflammation
5) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.70 Pain Relevance 0.24

General Comments

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