INT213502

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.97
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Defa1) extracellular region (Defa1)
Anatomy Link Frequency
Paneth cell 1
Defa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 56 99.28 Very High Very High Very High
potassium channel 1 64.40 Quite High
Inflammation 47 61.04 Quite High
corticosteroid 10 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 98 99.84 Very High Very High Very High
Disease 70 98.96 Very High Very High Very High
Targeted Disruption 6 85.84 High High
Colitis 7 75.60 Quite High
Enteritis 1 73.28 Quite High
INFLAMMATION 39 61.04 Quite High
Celiac Disease 2 38.40 Quite Low
Infection 11 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 7 5.00 Very Low Very Low Very Low
Gastritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fellermann et al. [48] described a defensin deficiency in IBD, which could lead to an impaired intestinal barrier function and subsequently to the initiation of IBD.
Negative_regulation (deficiency) of defensin associated with inflammatory bowel disease
1) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.13 Pain Relevance 0.15
As the Paneth cell's foremost activity is the secretion of huge amounts of defensins, an attractive interrelation can be proposed for the decreased defensin functionality in Crohn's disease and the mutation in ATG16L1.
Negative_regulation (decreased) of defensin in Paneth cell associated with crohn's disease and disease
2) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.84 Pain Relevance 0.26

General Comments

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