INT213503

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.54
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
mammary gland 1
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 37 98.86 Very High Very High Very High
Inflammation 22 98.02 Very High Very High Very High
Kinase C 52 97.42 Very High Very High Very High
fibrosis 112 93.72 High High
antagonist 11 88.44 High High
Nicotine 12 87.84 High High
Glutamate receptor 4 59.92 Quite High
Central nervous system 25 57.12 Quite High
Potency 4 24.96 Low Low
bDMF 49 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 254 99.84 Very High Very High Very High
INFLAMMATION 28 98.02 Very High Very High Very High
Myocardial Infarction 138 96.56 Very High Very High Very High
Drug Induced Neurotoxicity 48 94.92 High High
Fibrosis 2 93.72 High High
Targeted Disruption 35 90.32 High High
Apoptosis 62 90.28 High High
Alzheimer's Dementia 20 88.60 High High
Craniofacial Abnormalities 1 86.04 High High
Neurodegenerative Disease 40 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
7-nAChR could be a target of the Wnt pathway by regulating the pre-synaptic localization of APC and ?
Regulation (target) of Wnt
1) Confidence 0.37 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.12 Pain Relevance 0.11
Several independent studies are consistent with the idea that Wnt signaling components are altered in AD [27-33].
Regulation (altered) of Wnt associated with disease
2) Confidence 0.22 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.66 Pain Relevance 0
Cross-talk with other signaling cascades that regulate Wnt/?
Regulation (regulate) of Wnt
3) Confidence 0.22 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2515306 Disease Relevance 0.52 Pain Relevance 0.09
as a clinical target in AD has been discussed, including the activation of M1 muscarinic receptor and PKC, the use of anti-inflammatory-ChE bifunctional compounds, PPAR agonists, and some antioxidants, all of which may play a role by regulating the Wnt/?
Regulation (regulating) of Wnt associated with kinase c, inflammation, agonist and disease
4) Confidence 0.22 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.55 Pain Relevance 0.23
Modulation of the Wnt Signaling Pathway

Antisclerostin AntibodyA large family of extracellular glycoproteins, called Wnt proteins, are key regulators of bone remodeling and other cellular processes [95–97].

Regulation (Modulation) of Wnt
5) Confidence 0.03 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.27 Pain Relevance 0.04
In addition to regulating Sox-2, Wnt-?
Regulation (regulating) of Wnt
6) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.09 Pain Relevance 0.04
As indicated, different Wnt-dependent and -independent stimuli seem to interact with GSK3?
Regulation (different) of Wnt
7) Confidence 0.03 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.61 Pain Relevance 0.05
Whether we can enhance the cardiac repair by modulating Wnt remains the question since active Wnt signaling was present in all the cell populations studied.
Regulation (modulating) of Wnt
8) Confidence 0.03 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.49 Pain Relevance 0
These include the mammary gland, where the functions of both Lrp5 and Lrp6 are linked to mammary progenitor cell regulation and where the proteins appear to function in at least a partially redundant fashion and affect the levels of Wnt/?
Regulation (affect) of Wnt in mammary gland
9) Confidence 0.01 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox