INT213507

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.41
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pax2) nucleus (Pax2) DNA binding (Pax2)
protein complex (Pax2) microtubule organizing center (Pax2) lysosome (Pax2)
Anatomy Link Frequency
otic placodes 2
spinal cord 1
epibranchial placode 1
Pax2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 62 99.34 Very High Very High Very High
substantia gelatinosa 6 77.44 Quite High
bDMF 196 76.76 Quite High
Nerve growth factor 24 72.36 Quite High
GABAergic 21 69.88 Quite High
Pain 12 36.88 Quite Low
cytokine 100 34.88 Quite Low
gABA 28 30.80 Quite Low
Dorsal horn 9 22.56 Low Low
Dorsal horn neuron 4 9.20 Low Low
Disease Link Frequency Relevance Heat
Necrosis 168 85.80 High High
Ganglion Cysts 186 85.32 High High
Injury 52 77.04 Quite High
Lung Cancer 1 66.32 Quite High
Apoptosis 54 66.04 Quite High
Increased Venous Pressure Under Development 2 57.24 Quite High
Pain 12 36.88 Quite Low
Death 31 5.00 Very Low Very Low Very Low
INFLAMMATION 30 5.00 Very Low Very Low Very Low
Targeted Disruption 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since Pax2 expression is present in both the epibranchial and otic placodes, it must cooperate with other factors to specify epibranchial placode identity.
Gene_expression (expression) of Pax2 in epibranchial placode
1) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.23 Pain Relevance 0
Pax2 and Pax8 are expressed in the posterior placodal region, where the epibranchial and otic placodes are derived [10].
Gene_expression (expressed) of Pax2 in otic placodes
2) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.30 Pain Relevance 0
Because Pax2 expression is more restricted than the pan-placodally expressed genes, it may be important for conferring placodal identity.
Gene_expression (expression) of Pax2
3) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.26 Pain Relevance 0
Genes such as PAX2, NPHS1 and lectins like Dolicholus Biflorus and Peanut Agglutinin are expressed by injected cells, indicating that at least some of the integrated cells are able to commit toward renal differentiation.
Gene_expression (expressed) of PAX2
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.35 Pain Relevance 0
Six1 and Eya1 regulate specification of the pan-placodal region, and Pax2 may confer additional specification upon this region to produce the epibranchial and otic placodes.
Gene_expression (produce) of Pax2 in otic placodes
5) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.21 Pain Relevance 0.14
Primer pairs for Lbx1, activated targets (Pax2, Lmx1b, Pax8, Pax2?
Gene_expression (targets) of Pax2
6) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0.03
Primer pairs for Lbx1, activated targets (Pax2, Lmx1b, Pax8, Pax2?
Gene_expression (targets) of Pax2
7) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0.03
Moreover, the two paralogs of Pax2, namely Pax8 and Pax5, were expressed at 10.2 and 1.7 fold lower levels in mutant green cells.
Gene_expression (expressed) of Pax2
8) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0.04
Injected hAFSC expressed NPHS1, AQP2, PAX2, and OCLN, when compared to hAFSC before injection (Figure 4F).
Gene_expression (expressed) of PAX2
9) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0 Pain Relevance 0
Lhx1 and Lhx5 are expressed in inhibitory interneurons of the dorsal spinal cord and have been shown to increase expression of Pax2.
Gene_expression (expression) of Pax2 in spinal cord associated with spinal cord
10) Confidence 0.27 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.07 Pain Relevance 0.11

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