INT21351

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Context Info
Confidence 0.19
First Reported 1989
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.14
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
peptic ulcer disease 1 75.92 Quite High
anesthesia 1 67.72 Quite High
depression 1 59.96 Quite High
aspirin 2 50.00 Quite Low
Angina 2 50.00 Quite Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 4 100.00 Very High Very High Very High
Duodenal Ulcer 6 92.96 High High
Disease 1 75.92 Quite High
Stress 1 64.28 Quite High
Depression 1 59.96 Quite High
Sepsis 1 57.72 Quite High
Infection 1 57.28 Quite High
Cv General 3 Under Development 2 53.60 Quite High
Acute Coronary Syndrome 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 11 patients PAF, LTB4, and LTC4 generation was also assessed after 4 weeks of treatment resulting in ulcer healing and found to be significantly reduced when compared with their synthesis when the ulcer was active.
Negative_regulation (reduced) of Gene_expression (generation) of LTC4 associated with ulcers
1) Confidence 0.19 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.85 Pain Relevance 0.08
The LTC4 production, by contrast, significantly decreased postoperatively.
Negative_regulation (decreased) of Gene_expression (production) of LTC4
2) Confidence 0.06 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2603790 Disease Relevance 0.24 Pain Relevance 0.10
Glucocorticoids can suppress LTC4 biosynthesis in the short term and may provide an interesting tool to explore the pathophysiological significance of inflammatory cell activation in this setting.


Negative_regulation (suppress) of Gene_expression (biosynthesis) of LTC4
3) Confidence 0.03 Published 2003 Journal Circulation Section Body Doc Link 12515743 Disease Relevance 0.05 Pain Relevance 0

General Comments

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