INT213519

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.15
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tlx3) DNA binding (Tlx3)
Anatomy Link Frequency
neurons 3
Tlx3 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 6 99.24 Very High Very High Very High
Dorsal horn 3 85.36 High High
Spinal cord 10 83.84 Quite High
bDMF 147 80.48 Quite High
GABAergic 3 79.92 Quite High
chemokine 20 75.68 Quite High
Neurotransmitter 3 69.28 Quite High
Nerve growth factor 18 18.84 Low Low
nociceptor 6 13.80 Low Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 12 97.88 Very High Very High Very High
Ganglion Cysts 132 96.20 Very High Very High Very High
Disease 88 95.64 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 16 93.48 High High
Lymphatic System Cancer 488 91.80 High High
Leukemia 28 90.28 High High
T-cell Lymphoma 84 89.16 High High
Cancer 164 84.16 Quite High
Mantle-cell Lymphoma 132 81.00 Quite High
Plasmacytoma 8 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note that, later in development, Tlx3 expression is lost from many brainstem areas, but high expression is maintained in the rostral (gustatory) NTS, suggesting that Tlx3 may play a role in the later differentiation of neurons.
Gene_expression (expression) of Tlx3 in neurons associated with medulla
1) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.21
In addition to Phox2b, neurons of the NST also express another homeobox gene, Tlx3 [131].
Gene_expression (express) of Tlx3 in neurons
2) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.17
The transcription factor Tlx3 is also expressed by rostral NST, and it may regulate the development of specific NST neuron phenotypes.


Gene_expression (expressed) of Tlx3 in neuron
3) Confidence 0.55 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.10 Pain Relevance 0.07
In 286 adult T-ALL patients enrolled into the German Multicenter ALL therapy protocols, high HOX11 expression and HOX11L2 expression were predominantly seen in thymic T-ALL.
Gene_expression (expression) of HOX11L2
4) Confidence 0.11 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.29 Pain Relevance 0.03
Thus, patients with aberrant HOX11L2 expression should be considered early as candidates for intensified treatment regimes [58].
Gene_expression (expression) of HOX11L2
5) Confidence 0.11 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.14 Pain Relevance 0.04
In a multivariate analysis, HOX11L2 expression proved to be an independent adverse risk factor for relapse-free and overall survival.
Gene_expression (expression) of HOX11L2 associated with recurrence
6) Confidence 0.11 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.23 Pain Relevance 0.03
The prognostic impact of HOX11 and HOX11L2 expression has been an area of controversy.
Gene_expression (expression) of HOX11L2
7) Confidence 0.11 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.39 Pain Relevance 0

General Comments

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