INT213534

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.79
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Ctnnd2) nucleus (Ctnnd2)
Ctnnd2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 74.56 Quite High
cytokine 31 59.24 Quite High
Inflammation 64 58.84 Quite High
bDMF 49 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 59 99.84 Very High Very High Very High
Colon Cancer 12 98.64 Very High Very High Very High
Cancer 203 98.48 Very High Very High Very High
Adenocarcinoma 9 96.12 Very High Very High Very High
Mesothelioma 110 94.32 High High
Targeted Disruption 12 90.08 High High
Familial Adenomatous Polyposis 5 84.80 Quite High
Colorectal Cancer 36 77.24 Quite High
Ovarian Cancer 2 73.32 Quite High
Breast Cancer 11 63.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin is activated.
Positive_regulation (activated) of catenin
1) Confidence 0.67 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.74 Pain Relevance 0
-catenin is induced up to 2.5-folds at 24 hours time point, already at a concentration of 0.1 nM of DHT.
Positive_regulation (induced) of catenin
2) Confidence 0.67 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.43 Pain Relevance 0
-catenin is either caused by mutational inactivation of the AP C tumor suppressor gene or by mutation of ?
Positive_regulation (caused) of catenin associated with cancer
3) Confidence 0.49 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.83 Pain Relevance 0.03
-catenin, excessive activation of endogenous Stat3 may only promote tumour growth in conjunction with preexisting tumour-initiating mutation(s).
Positive_regulation (activation) of catenin associated with cancer
4) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.34 Pain Relevance 0.09
-catenin activation which results in transcriptional activation of Lef1 and Tcf transcription factors.
Positive_regulation (activation) of catenin
5) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.04
-catenin was significantly increased in adenomas compared to normal mucosa leading to an IRS of 1.4 (± 0.2) vs. 0.5 (± 0.1) in the control group (H2O) (P ?
Positive_regulation (increased) of catenin associated with adenoma
6) Confidence 0.45 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.46 Pain Relevance 0
-catenin accumulation.
Positive_regulation (accumulation) of catenin
7) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0

General Comments

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