INT213537

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sox2) anatomical structure formation involved in morphogenesis (Sox2) nucleus (Sox2)
DNA binding (Sox2) transcription factor binding (Sox2) cytoplasm (Sox2)
Anatomy Link Frequency
papillae 2
stem cells 2
Sox2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 83.88 Quite High
bDMF 49 5.00 Very Low Very Low Very Low
imagery 21 5.00 Very Low Very Low Very Low
Action potential 11 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 72 98.68 Very High Very High Very High
Teratoma 10 94.08 High High
Glioblastoma 18 92.16 High High
Death 14 90.40 High High
Stress 10 89.76 High High
Malignant Neoplastic Disease 5 88.96 High High
Glioma 45 86.96 High High
Targeted Disruption 12 81.12 Quite High
Brain Tumor 60 71.04 Quite High
Pressure And Volume Under Development 1 15.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of Sox2 increases fungiform papillae at the expense of filiform papillae development.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Sox2 in papillae
1) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.08 Pain Relevance 0.04
In our microarray analysis, we observed high expression of pluripotency-related genes involved in the core hESC regulatory circuitry, including OCT4, SOX2, and NANOG, as well as CRYPTO 1 and 3, LCK, and HESX1.
Positive_regulation (high) of Gene_expression (expression) of SOX2
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.18 Pain Relevance 0
GBs frequently overexpress genes typical of neural stem cells including Sox2 [106], Myc [27] and Oct4 [107].
Positive_regulation (overexpress) of Gene_expression (overexpress) of Sox2 in stem cells
3) Confidence 0.22 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.08 Pain Relevance 0

General Comments

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