INT213578

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 45.20 Quite Low
alcohol 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 15 99.16 Very High Very High Very High
Death 30 94.24 High High
Stress 11 92.84 High High
Reprotox - General 3 1 89.84 High High
Aging 73 88.60 High High
Glioma 104 86.52 High High
Diabetes Mellitus 3 82.68 Quite High
Disease 3 79.92 Quite High
Cancer 145 73.00 Quite High
Lifespan 9 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SIRT1 increased FOXO3A ability to induce cell cycle arrest and enhanced expression of a FOXO3A target involved in DNA repair, such as GADD45 [24].
FOXO3A Binding (ability) of
1) Confidence 0.33 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.50 Pain Relevance 0
Finally, the untargeted approach to SNP selection also identified a SNP near FOXO3a associated with age at natural menopause.
FOXO3a Binding (associated) of associated with endometriosis (extended)
2) Confidence 0.27 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995604 Disease Relevance 0.99 Pain Relevance 0
Recent data show FOXO3a directly regulates p27kip1 transcription [53], [54], suggesting that reduced p27kip1 levels after a proliferative stimulus may also be associated with FOXO3a.
FOXO3a Binding (associated) of
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.21 Pain Relevance 0
It is known that FOXO3a regulates the transcription of p27kip1 by binding to its promoter [57].
FOXO3a Binding (binding) of
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.09 Pain Relevance 0
We also show that increased expression of p27Kip1 is due to the efficient binding of FOXO3a on its promoter, which was analyzed by the luciferase expression.


FOXO3a Binding (binding) of
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.27 Pain Relevance 0
Our study indicates that cathepsin B and uPAR knockdown induces G0/G1 arrest by modulating the PI3K/AKT signaling pathway and further increases expression of p27Kip1 accompanied by the binding of FOXO3a to its promoter.
FOXO3a Binding (binding) of
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox