INT2136

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Context Info
Confidence 0.77
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 9.83
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga)
Anatomy Link Frequency
neuron 2
Leydig cells 2
ventromedial hypothalamic nucleus 1
nerves 1
germ cells 1
Cga (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 4 99.62 Very High Very High Very High
narcan 22 99.08 Very High Very High Very High
palliative 10 98.88 Very High Very High Very High
abdominal pain 5 98.68 Very High Very High Very High
headache 3 91.60 High High
cva 7 90.24 High High
antagonist 12 79.80 Quite High
Opioid 3 79.36 Quite High
withdrawal 21 73.68 Quite High
agonist 5 60.60 Quite High
Disease Link Frequency Relevance Heat
Cancer 206 100.00 Very High Very High Very High
Hepatomegaly 1 99.68 Very High Very High Very High
Precocious Puberty 10 99.66 Very High Very High Very High
Pinealoma 12 99.64 Very High Very High Very High
Dysgerminoma 24 99.56 Very High Very High Very High
Reprotox - General 1 172 99.48 Very High Very High Very High
Recurrence 10 98.86 Very High Very High Very High
Abdominal Pain 5 98.68 Very High Very High Very High
Colon Cancer 4 98.64 Very High Very High Very High
Tubal Pregnancy 3 97.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistologically, however, no HCG was detected.
Neg (no) Gene_expression (detected) of HCG
1) Confidence 0.77 Published 1990 Journal Gan No Rinsho Section Abstract Doc Link 2381047 Disease Relevance 0.80 Pain Relevance 0.09
Unilateral intratesticular injection of naloxone (10 micrograms) similarly enhanced basal and hCG-stimulated testosterone production by Leydig cells, but production was not modified in Leydig cells from the contralateral vehicle-injected testis, nor was it changed when the same dose was injected subcutaneously.
Gene_expression (production) of hCG in Leydig cells associated with narcan
2) Confidence 0.60 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485243 Disease Relevance 0 Pain Relevance 0.39
In vitro exposure of Leydig cells to increasing doses of naloxone (10(-9) to 10(-7) M) did not alter either basal or hCG-stimulated testosterone production.
Gene_expression (production) of hCG in Leydig cells associated with narcan
3) Confidence 0.60 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485243 Disease Relevance 0 Pain Relevance 0.44
The purpose of the study was to evaluate the effects of drug therapy on the throphoblast and on the tubal wall when protaglandin F2 alpha (PGF2 alpha) was administered in cases of tubal pregnancies. 42 patients were divided into two groups: women of group I (n = 30) were secondarily treated by surgery because of raising serum HCG levels.
Gene_expression (levels) of HCG associated with tubal pregnancy
4) Confidence 0.59 Published 1995 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 8582584 Disease Relevance 0.48 Pain Relevance 0.14
HCG was detected by IF in 4 tumors with an apocrine cytologic cell type.
Gene_expression (detected) of HCG associated with cancer
5) Confidence 0.34 Published 1978 Journal Cancer Section Abstract Doc Link 361213 Disease Relevance 1.00 Pain Relevance 0.06
No raised serum HCG levels were found.
Gene_expression (levels) of HCG
6) Confidence 0.34 Published 1978 Journal Cancer Section Abstract Doc Link 361213 Disease Relevance 1.07 Pain Relevance 0.10
In contrast, DEX reduced basal and hCG-stimulated beta EP production (by approximately 50%).
Gene_expression (production) of hCG associated with dexamethasone
7) Confidence 0.20 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.28
In order to determine whether the in vitro findings of the potential involvement of SphK1 in NE differentiation had any relevance to human disease, sections from a representative patient who underwent palliative transurethral resection for local recurrence under complete androgen blockade were immunostained for CgA and SphK1 expression (Fig. 8).
Gene_expression (expression) of CgA associated with disease, recurrence and palliative
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.34 Pain Relevance 0.13
In addition to morphological characteristics, transdifferentiated NE-like prostate cancer cells are defined by the expression of a number of neurosecretory products including chromogranin A (CgA) and neuron-specific enolase (NSE).
Gene_expression (expression) of CgA in neuron associated with reprotox - general 1
9) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.10 Pain Relevance 0.09
In addition to morphological characteristics, transdifferentiated NE-like prostate cancer cells are defined by the expression of a number of neurosecretory products including chromogranin A (CgA) and neuron-specific enolase (NSE).
Gene_expression (products) of CgA in neuron associated with reprotox - general 1
10) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.10 Pain Relevance 0.09
Consistent with previous observations [41], [44], immunoblots showed that CgA expression was very low in both parental LNCaP (Fig. 6A, lower panel) and C4-2B (Figure S1) cells, while its expression level was greatly enhanced over time in hormone-deficient medium.
Gene_expression (expression) of CgA
11) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.09 Pain Relevance 0.06
Co-expression of CgA in blue with brown SphK1 resulted in intense dark brown signal (solid arrowhead).
Gene_expression (expression) of CgA
12) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.35 Pain Relevance 0.11
Bilateral destruction of the LPO or LHA did not eliminate the osmosensitivity characteristics of LPO or LHA units, demonstrating that units of either area do not require input from the opposite area for osmosensitivity.
Gene_expression (destruction) of LHA
13) Confidence 0.17 Published 1976 Journal Brain Res. Bull. Section Abstract Doc Link 974803 Disease Relevance 0 Pain Relevance 0
A female case of the HCG-producing ectopic pinealoma associated with precocious puberty.
Gene_expression (producing) of HCG associated with precocious puberty and pinealoma
14) Confidence 0.10 Published 1976 Journal Endocrinol. Jpn. Section Title Doc Link 991833 Disease Relevance 1.05 Pain Relevance 0.09
A female case of precocious puberty associated with HCG-producing ectopic pinealoma was reported.
Gene_expression (producing) of HCG associated with pinealoma and precocious puberty
15) Confidence 0.10 Published 1976 Journal Endocrinol. Jpn. Section Abstract Doc Link 991833 Disease Relevance 0.71 Pain Relevance 0.09
HCG content in the tumor was as high was 400 ng/mg of acetone dried tumor tissue, but no FSH was detectable.
Gene_expression (detectable) of HCG associated with cancer
16) Confidence 0.09 Published 1976 Journal Endocrinol. Jpn. Section Abstract Doc Link 991833 Disease Relevance 1.12 Pain Relevance 0.08
Serum levels of CEA and serum and urine levels of beta-HCG were markedly elevated.
Gene_expression (levels) of HCG in urine
17) Confidence 0.08 Published 1980 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6990747 Disease Relevance 0.46 Pain Relevance 0.10
OX1R and OX2R are present in the lateral hypothalamic area (LHA), which is rich in orexin-positive nerves [13].
Gene_expression (present) of LHA in nerves
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.21 Pain Relevance 0
In the hypothalamic region, OX1R mRNA is located mainly in the dorsomedial area of the ventromedial hypothalamic nucleus (VMH) and the anterior hypothalamic territory, whereas, OX2R mRNA is observed in several hypothalamic nuclei including the arcuate nucleus, posteroventricular nucleus, LHA, and tuberomammilary bodies [13].
Gene_expression (observed) of LHA in ventromedial hypothalamic nucleus
19) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.24 Pain Relevance 0.09
The prognostic value of CEA, beta HCG, AFP, CA125, CA19-9 and C-erb B-2, beta HCG immunohistochemistry in advanced colorectal cancer.
Gene_expression (value) of HCG associated with colon cancer
20) Confidence 0.05 Published 1995 Journal Ann. Oncol. Section Title Doc Link 8573538 Disease Relevance 0.19 Pain Relevance 0.09

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