INT213647

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.48
Pain Relevance 0

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peptidase activity (F9) extracellular region (F9) plasma membrane (F9)
Anatomy Link Frequency
muscle 2
plasma 1
blood 1
platelets 1
F9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 22 50.00 Quite Low
cva 6 50.00 Quite Low
headache 1 48.20 Quite Low
rheumatoid arthritis 15 39.68 Quite Low
Osteoarthritis 5 8.00 Low Low
Etanercept 20 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Adalimumab 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematoma 42 99.96 Very High Very High Very High
Injury 14 99.80 Very High Very High Very High
Coagulation Disorder 108 99.60 Very High Very High Very High
Factor Ix Deficiency 15 97.98 Very High Very High Very High
Hemorrhage 56 91.12 High High
Disease 159 87.04 High High
Retina Disease 40 83.60 Quite High
Infection 7 82.00 Quite High
Chronic Subdural Hematoma 43 78.40 Quite High
Toxicity 3 77.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By directly activating FX on the surface of activated platelets at the site of injury (thereby bypassing FVIII and FIX), rFVIIa can circumvent the actions of inhibitory antibodies present in patients with acquired hemophilia [2].
Gene_expression (bypassing) of FIX in platelets associated with coagulation disorder and injury
1) Confidence 0.65 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918632 Disease Relevance 0.79 Pain Relevance 0
When compared with the normal range for plasma, factor II in the hematoma was normal in one, decreased in 12, and was less than 1% in one hematoma; factor V was normal in two, decreased in 11, and was less than 1% in two hematomas; factor VII was normal in three and decreased in 10; factor VIII was normal in two and decreased in 11, and was less than 1% in three hematomas; factor IX was normal in three and decreased in 10; factor X was normal in one and decreased in 12; factor XI was normal in five and decreased in eight; factor XII was increased in one, normal in nine, and decreased in three.
Gene_expression (decreased) of factor IX in plasma associated with hematoma
2) Confidence 0.65 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.05 Pain Relevance 0
To attain both long-term and therapeutic levels of FIX expression in these dogs, researchers found success by using adeno-associated viral (AAV) vectors (Herzog et al. 1999; Snyder et al. 1999; Wang et al. 2000).
Gene_expression (expression) of FIX
3) Confidence 0.45 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.59 Pain Relevance 0
The first of these utilized a retroviral vector containing FIX cDNA and resulted in long-term expression of low levels of FIX (Kay et al. 1993).
Gene_expression (expression) of FIX
4) Confidence 0.45 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.56 Pain Relevance 0
A subsequent study used a recombinant adenoviral vector and achieved short-term expression of therapeutic levels of FIX (Kay et al. 1994).
Gene_expression (expression) of FIX
5) Confidence 0.45 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.65 Pain Relevance 0
FIX, synthesized by hepatocytes, is an essential part of the blood coagulation cascade.
Gene_expression (synthesized) of FIX in blood
6) Confidence 0.39 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 1.14 Pain Relevance 0
Haemophilia B patients receiving intramuscular injections of AAV encoding FIX were shown to have consistent local expression of FIX up to 3.7 years following delivery [11].
Gene_expression (expression) of FIX associated with factor ix deficiency
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.38 Pain Relevance 0
In hemophilia B dogs, factor IX (FIX) was recovered >4 years following AAV2-FIX injection in both muscle biopsies and circulation.
Gene_expression (injection) of FIX in muscle associated with coagulation disorder
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.39 Pain Relevance 0
In hemophilia B dogs, factor IX (FIX) was recovered >4 years following AAV2-FIX injection in both muscle biopsies and circulation.
Gene_expression (injection) of FIX in muscle associated with coagulation disorder
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.38 Pain Relevance 0
This led to transient transaminitis and loss of factor IX expression [27].
Gene_expression (expression) of factor IX
10) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.55 Pain Relevance 0

General Comments

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