INT21367

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Context Info
Confidence 0.27
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.77
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
anterior 1
brain 1
AHA (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 32 100.00 Very High Very High Very High
spinal inflammation 9 99.84 Very High Very High Very High
agonist 1 98.60 Very High Very High Very High
narcan 10 97.10 Very High Very High Very High
antagonist 1 96.92 Very High Very High Very High
opioid receptor 2 96.70 Very High Very High Very High
Arthritis 3 91.08 High High
noradrenaline 4 56.72 Quite High
Endogenous opioid 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Low Back Pain 9 99.84 Very High Very High Very High
Heart Rate Under Development 2 99.54 Very High Very High Very High
Hypertension 24 99.22 Very High Very High Very High
Uveitis 3 97.76 Very High Very High Very High
Pressure And Volume Under Development 1 95.72 Very High Very High Very High
Crystal Associated Disease 3 91.08 High High
Insulin Resistance 1 81.20 Quite High
Congenital Anomalies 3 62.12 Quite High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of alpha(2)-adrenoceptors in the anterior hypothalamic area (AHA) decreases sympathetic nervous system activity and blood pressure.
Positive_regulation (Activation) of AHA in blood
1) Confidence 0.27 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17683864 Disease Relevance 0.25 Pain Relevance 0.19
The purpose of this study was to examine the roles of brain opioid receptors, using the opioid receptor antagonist naloxone, and brain alpha 2 adrenergic and imidazole receptors, using their agonist clonidine, in the hypertension and tachycardia induced by electrical stimulation of the AHA and PHA area.
Positive_regulation (stimulation) of AHA in brain associated with heart rate under development, antagonist, hypertension, agonist, narcan, opioid receptor and clonidine
2) Confidence 0.15 Published 1994 Journal Life Sci. Section Abstract Doc Link 8177007 Disease Relevance 0.20 Pain Relevance 0.66
Thus, dietary Ca2+ supplementation prevents the NaCl-induced exacerbation of hypertension and augmented depressor response to clonidine in SHR-S by increasing noradrenergic input to AHA, thereby preventing the upregulation of AHA alpha 2-adrenoceptors.
Positive_regulation (upregulation) of AHA associated with hypertension and clonidine
3) Confidence 0.12 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 2171566 Disease Relevance 0.25 Pain Relevance 0.41
AHA levels were much more elevated in AS patients with present illness or past history of uveitis than in those without.
Positive_regulation (elevated) of AHA associated with spinal inflammation and uveitis
4) Confidence 0.08 Published 1994 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 7867427 Disease Relevance 1.16 Pain Relevance 0.92
Clonidine was microinjected into the AHA of rats maintained on the four diets for 2 weeks to test the hypothesis that dietary Ca2+ supplementation prevents the previously observed NaCl-induced upregulation of alpha 2-adrenoceptors in AHA.
Positive_regulation (upregulation) of AHA associated with clonidine
5) Confidence 0.07 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 2171566 Disease Relevance 0.40 Pain Relevance 0.41
Thus, dietary Ca2+ supplementation prevents the NaCl-induced exacerbation of hypertension and augmented depressor response to clonidine in SHR-S by increasing noradrenergic input to AHA, thereby preventing the upregulation of AHA alpha 2-adrenoceptors.
Positive_regulation (increasing) of AHA associated with hypertension and clonidine
6) Confidence 0.07 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 2171566 Disease Relevance 0.25 Pain Relevance 0.42
Our previous studies demonstrated that (a) dietary Ca2+ supplementation prevents the rise in blood pressure, activation of sympathetic outflow, and reductions in anterior hypothalamic norepinephrine (NE) content and release induced in NaCl-sensitive spontaneous hypertensive rats (SHR-S) by dietary NaCl loading; and (b) stimulation of alpha 2-adrenoceptors by microinjection of clonidine into the anterior hypothalamic area (AHA) results in an exaggerated depressor response in SHR-S fed a high NaCl diet as compared with SHR-S on a basal diet.
Positive_regulation (stimulation) of AHA in anterior associated with pressure and volume under development, hypertension and clonidine
7) Confidence 0.01 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468929 Disease Relevance 0.27 Pain Relevance 0.23

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