INT213676

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.95
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 99.56 Very High Very High Very High
imagery 11 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Cancer 36 94.92 High High
Cancer 132 88.76 High High
Small Cell Lung Cancer 126 88.48 High High
Stomach Cancer 5 82.60 Quite High
Adenocarcinoma 14 80.72 Quite High
Disease 19 64.80 Quite High
Skin Cancer 9 58.24 Quite High
Apoptosis 18 54.00 Quite High
Breast Cancer 6 42.96 Quite Low
Lung Cancer 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Negative_regulation (decrease) of Gene_expression (protein) of thymidylate synthase associated with qutenza
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.67 Pain Relevance 0.92
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Negative_regulation (decrease) of Gene_expression (expression) of thymidylate synthase associated with qutenza
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.67 Pain Relevance 0.91
Joshi et al., measured gene expressions of thymidylate synthase 1 (TS1), glutathione S-transferase ?
Negative_regulation (Joshi) of Gene_expression (expressions) of thymidylate synthase 1
3) Confidence 0.05 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.62 Pain Relevance 0

General Comments

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