INT213681

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 8.96
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
Anatomy Link Frequency
lymph node 2
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 99.24 Very High Very High Very High
methotrexate 40 98.96 Very High Very High Very High
adenocard 3 83.52 Quite High
Pain 4 82.64 Quite High
Inflammation 20 82.00 Quite High
chemokine 16 78.04 Quite High
palliative 9 62.40 Quite High
rheumatoid arthritis 63 59.52 Quite High
cytokine 28 5.00 Very Low Very Low Very Low
Infliximab 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 331 99.00 Very High Very High Very High
Colon Cancer 254 98.84 Very High Very High Very High
Mesothelioma 47 98.16 Very High Very High Very High
Metastasis 38 97.66 Very High Very High Very High
Esophageal Cancer 36 93.80 High High
Recurrence 43 88.24 High High
Small Cell Lung Cancer 126 87.84 High High
Toxicity 41 87.60 High High
Breast Cancer 22 85.68 High High
Disease 62 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This deletion may be associated with decreased TYMS mRNA stability and expression [72], thereby increasing MTX efficacy [66].
Gene_expression (expression) of TYMS associated with methotrexate
1) Confidence 0.33 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.27 Pain Relevance 0.46
In vitro, the 3G containing genotype showed a higher TS mRNA expression [19,20].
Gene_expression (expression) of TS mRNA
2) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.22 Pain Relevance 0
Several polymorphisms in TS may influence TS mRNA transcription, stability, or protein expression.
Gene_expression (expression) of TS mRNA
3) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.50 Pain Relevance 0.06
It is interesting that SAHA represses the gene for thymidylate synthase, the principal target of pemetrexed.
Gene_expression (represses) of thymidylate synthase
4) Confidence 0.20 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 0.76 Pain Relevance 0.08
Sharma et al reported that 5-FU resistance was stronger in patients with overexpression of either TYMS mRNA or protein.35 Although the relation between TYMS with lymph node metastasis is not clear, we are now analyzing its relationship with cancer resistance, as we observed the copy number gain and overexpression of TYMS more frequently in advanced CRC cases.
Gene_expression (overexpression) of TYMS mRNA in lymph node associated with cancer, colon cancer and metastasis
5) Confidence 0.18 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.25 Pain Relevance 0
Sharma et al reported that 5-FU resistance was stronger in patients with overexpression of either TYMS mRNA or protein.35 Although the relation between TYMS with lymph node metastasis is not clear, we are now analyzing its relationship with cancer resistance, as we observed the copy number gain and overexpression of TYMS more frequently in advanced CRC cases.
Gene_expression (overexpression) of TYMS in lymph node associated with cancer, colon cancer and metastasis
6) Confidence 0.15 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.23 Pain Relevance 0
However, the expression of TYMS is up-regulated in most cancers, which, in turn, makes tumor cells resistant to 5-FU treatment.
Gene_expression (expression) of TYMS associated with cancer
7) Confidence 0.15 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.37 Pain Relevance 0
RALBP1, TYMS, RAB12 and RNMT were extracted as Gene Set III-N (N0 vs.
Gene_expression (extracted) of TYMS
8) Confidence 0.15 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.39 Pain Relevance 0.04
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Gene_expression (protein) of thymidylate synthase associated with qutenza
9) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.64 Pain Relevance 0.90
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Gene_expression (expression) of thymidylate synthase associated with qutenza
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.66 Pain Relevance 0.91
Joshi et al., measured gene expressions of thymidylate synthase 1 (TS1), glutathione S-transferase ?
Gene_expression (expressions) of thymidylate synthase 1
11) Confidence 0.09 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.61 Pain Relevance 0
Recently, both Smp_121920 (vesicular amine transporter) and Smp_135460 (bifunctional dihydrofolate reductase-thymidylate synthase) were found to be minimally expressed in the schistosomula lifecycle stage as determined by DNA microarray analysis of the parasite lifecycle [22].
Gene_expression (expressed) of reductase-thymidylate synthase
12) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910722 Disease Relevance 0.07 Pain Relevance 0

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