INT213682

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.18
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 84.56 Quite High
imagery 11 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 174 98.28 Very High Very High Very High
Disease 21 98.24 Very High Very High Very High
Adhesions 14 97.96 Very High Very High Very High
Adenocarcinoma 48 95.28 Very High Very High Very High
Esophageal Cancer 34 93.44 High High
Apoptosis 18 85.44 High High
INFLAMMATION 5 84.56 Quite High
Malignant Neoplastic Disease 10 79.28 Quite High
Metastasis 38 72.08 Quite High
Pancreatic Cancer 56 58.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, some amplified genes (MEMO1, IGFP6, TBK1, MIB1, RIOK3), determined by the DNA chip array demonstrated high level of RNA overexpression as well.


Positive_regulation (overexpression) of Gene_expression (overexpression) of TBK1
1) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.66 Pain Relevance 0
Thus, the overexpression of the MEMO1 and the TBK1 genes in PaCa 5061 cells could be associated with the high tumorigenic and metastatic nature of these cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TBK1
2) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.54 Pain Relevance 0
More recently Izzo et al., found that activated NF-KB expression was significantly associated with residual disease following neo-adjuvant CRT (p = 0.006), metastatic progression (p = 0.01) and reduced survival (p = 0.01) in 80 oesophageal cancer patients [58].



Positive_regulation (activated) of Gene_expression (expression) of NF-KB associated with esophageal cancer and disease
3) Confidence 0.07 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.97 Pain Relevance 0.04

General Comments

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