INT213691

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 4.07
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cnp) plasma membrane (Cnp) intracellular (Cnp)
kinase activity (Cnp) cytoplasm (Cnp)
Anatomy Link Frequency
oligodendrocytes 3
SHED 1
stem cells 1
Cnp (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 80 92.08 High High
bradykinin 21 71.88 Quite High
agonist 26 70.52 Quite High
Hippocampus 13 41.48 Quite Low
Neuritis 36 39.48 Quite Low
Multiple sclerosis 82 6.08 Low Low
metalloproteinase 87 5.00 Very Low Very Low Very Low
Inflammation 40 5.00 Very Low Very Low Very Low
Demyelination 40 5.00 Very Low Very Low Very Low
Central nervous system 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 2 100.00 Very High Very High Very High
Multiple Sclerosis 396 98.76 Very High Very High Very High
Obesity 4 96.64 Very High Very High Very High
Hypotension 21 88.40 High High
Natriuresis 15 85.72 High High
Systemic Lupus Erythematosus 64 78.72 Quite High
Graft Vs Host Disease 4 74.48 Quite High
Disease 52 74.24 Quite High
Immune System Diseases 8 48.00 Quite Low
Apoptosis 14 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the CC, most TUNEL+ cells were NG2+ glial progenitors, followed by oligodendrocytes (recognized by expression of 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) or myelin basic protein) and then by GFAP+ cells (which were most probably astrocytes).
Gene_expression (expression) of CNPase in oligodendrocytes
1) Confidence 0.44 Published 2006 Journal J Biol Section Body Doc Link PMC2000477 Disease Relevance 0 Pain Relevance 0
Among the myelin proteins investigated, expression levels of MOG, MBP and MAG, except that of CNPase, were significantly attenuated in 6 week-old Olig1?
Gene_expression (levels) of CNPase
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.42 Pain Relevance 0.11
This speculation can be supported by the observation that not all myelin protein levels were affected; we have shown in this study that the expression levels of CNPase and PLP were unchanged in non-EAE adult Olig1?
Gene_expression (expression) of CNPase associated with multiple sclerosis
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.48 Pain Relevance 0.06
This speculation can be supported by the observation that not all myelin protein levels were affected; we have shown in this study that the expression levels of CNPase and PLP were unchanged in non-EAE adult Olig1?
Gene_expression (levels) of CNPase associated with multiple sclerosis
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.48 Pain Relevance 0.06
Among the myelin proteins investigated, expression levels of MOG, MBP and MAG, except that of CNPase, were significantly attenuated in 6 week-old Olig1?
Gene_expression (expression) of CNPase
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.42 Pain Relevance 0.11
GPR17+ cells were found to co-express either NG2 (arrows in Figure 4E), Olig2 (not shown), O4 (arrows in Figure 4F), or, to a lesser extent, CNPase (Figure 4G), confirming that they are indeed oligodendrocyte precursors.
Gene_expression (express) of CNPase in oligodendrocyte
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0.03
As neural crest cell-associated postnatal stem cells, SHED express a variety of neural cell markers including nestin, beta III tubulin, GAD, NeuN, GFAP, NFM, and CNPase [21].
Gene_expression (express) of CNPase in stem cells associated with generalized anxiety disorder
7) Confidence 0.15 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.77 Pain Relevance 0
To investigate in detail whether GPR17 is specifically expressed by pre-oligodendrocytes, we performed double staining experiments with a set of markers identifying different stages of differentiation, i.e., NG2 (oligodendrocyte precursor), O4 and CNPase (pre-oligodendrocytes, immature/mature cells), and MBP (mature oligodendrocytes) [22], [23].
Gene_expression (expressed) of CNPase in oligodendrocytes
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0.04
As neural crest cell-associated postnatal stem cells, SHED express a variety of neural cell markers including nestin, beta III tubulin, GAD, NeuN, GFAP, NFM, and CNPase [21].
Gene_expression (express) of CNPase in SHED associated with generalized anxiety disorder
9) Confidence 0.05 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.77 Pain Relevance 0
A similar percentage (~9%) was observed here for B. alternatus (Figure 8), for which 110 ESTs coded for BPP/CNP precursors (specifically the CNP region) while another 156 ESTs showed similarities only in the 3'UTR.
Gene_expression (precursors) of CNP
10) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.30 Pain Relevance 0.10
A similar percentage (~9%) was observed here for B. alternatus (Figure 8), for which 110 ESTs coded for BPP/CNP precursors (specifically the CNP region) while another 156 ESTs showed similarities only in the 3'UTR.
Gene_expression (precursors) of CNP
11) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.30 Pain Relevance 0.10
A similar situation applies to CNPs for which some peptidomic analyses have detected no such peptides in venom, despite the identification of transcripts in EST analyses, e.g., B. insularis [11] and L. muta ([111]; but cf. [10]) (see section on 'Inverted repeats' below for additional comment on CNP detection).


Gene_expression (detection) of CNP
12) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.12 Pain Relevance 0

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