INT2137

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 27
Total Number 29
Disease Relevance 19.22
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CeA 3
neurons 1
brain 1
synapses 1
parafollicular cells 1
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 183 100.00 Very High Very High Very High
gABA 72 100.00 Very High Very High Very High
GABAergic 48 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
antinociception 4 99.40 Very High Very High Very High
epidural 2 96.64 Very High Very High Very High
withdrawal 10 95.96 Very High Very High Very High
Chronic pancreatitis 4 95.52 Very High Very High Very High
alcohol 33 94.12 High High
addiction 28 93.84 High High
Disease Link Frequency Relevance Heat
Cancer 415 100.00 Very High Very High Very High
Disease 86 99.64 Very High Very High Very High
Neuroendocrine Cancer 2 98.60 Very High Very High Very High
Thyroid Neoplasm 8 97.96 Very High Very High Very High
Nociception 2 97.88 Very High Very High Very High
Abscess 3 97.04 Very High Very High Very High
Anxiety Disorder 29 96.16 Very High Very High Very High
Metastasis 37 96.08 Very High Very High Very High
Pancreatitis 5 95.52 Very High Very High Very High
Carotid Stenosis 18 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histologic examination showed papillary proliferations of well-differentiated, mucus-secreting cells that occasionally stained for carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9).
Localization (secreting) of CEA
1) Confidence 0.70 Published 1989 Journal Cancer Section Abstract Doc Link 2548703 Disease Relevance 0.70 Pain Relevance 0.09
In early stages of the disease, we unexpectedly found the elevated serum CEA and CA19-9.
Localization (found) of CEA associated with disease
2) Confidence 0.70 Published 2003 Journal No To Shinkei Section Abstract Doc Link 12833889 Disease Relevance 0.64 Pain Relevance 0.17
Mild CEA immunoreactivity and apical CEA localization were found significantly more often in Billroth II than in Billroth I stumps.
Localization (localization) of CEA
3) Confidence 0.68 Published 1998 Journal J. Surg. Res. Section Abstract Doc Link 9878336 Disease Relevance 0.31 Pain Relevance 0.08
Mice with deletion of NR1 in the CeA showed no obvious impairments in sensory, motor, or nociceptive function.
Localization (deletion) of CeA in CeA associated with nociception and amygdala
4) Confidence 0.66 Published 2010 Journal Vitam. Horm. Section Abstract Doc Link 20472137 Disease Relevance 0.59 Pain Relevance 1.53
In addition, the present study suggests that cholinergic transmission may activate the release of endorphins/enkephalins from interneurons of the CEA, resulting in antinociception.
Localization (release) of CEA in interneurons associated with antinociception, enkephalin and amygdala
5) Confidence 0.61 Published 2004 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15448880 Disease Relevance 0.12 Pain Relevance 0.92
Mild CEA immunoreactivity and apical CEA localization were found significantly more often in Billroth II than in Billroth I stumps.
Localization (localization) of CEA
6) Confidence 0.59 Published 1998 Journal J. Surg. Res. Section Abstract Doc Link 9878336 Disease Relevance 0.30 Pain Relevance 0.08
Intensive CEA immunoreactivity and cytoplasmatic localization were found significantly more often in Billroth I than in Billroth II stumps.
Localization (localization) of CEA
7) Confidence 0.59 Published 1998 Journal J. Surg. Res. Section Abstract Doc Link 9878336 Disease Relevance 0.30 Pain Relevance 0.07
Demographic data, presenting symptoms and their duration, pathological features of the tumour, tumour localization, histological data, pre-operative carcinoembryonic antigen (CEA) level, treatment modalities and survival data were scrutinized.
Localization (localization) of CEA associated with cancer
8) Confidence 0.59 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2954852 Disease Relevance 1.32 Pain Relevance 0
Thus, our data identify the involvement of the AC7 signaling pathway in both ethanol and CRF sensitivity of GABAergic synapses in CeA.


Localization (sensitivity) of CeA in synapses associated with gabaergic and amygdala
9) Confidence 0.58 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.13 Pain Relevance 0.35
Previously, we found that both ethanol and corticotropin releasing factor (CRF) increase GABAergic transmission in mouse and rat CeA neurons, in part by enhancing the release of GABA via activation of presynaptic CRF1 receptors.
Localization (transmission) of CeA in neurons associated with gaba, gabaergic and amygdala
10) Confidence 0.58 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.52
Patients underwent staged CABG and CEA were enrolled to Group 3 (n=40).
Localization (enrolled) of CEA
11) Confidence 0.55 Published 2009 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2678823 Disease Relevance 0.95 Pain Relevance 0.06
Patients underwent staged CABG and CEA were enrolled to Group 3 (n=40).
Localization (enrolled) of CEA
12) Confidence 0.55 Published 2009 Journal The Open Cardiovascular Medicine Journal Section Abstract Doc Link PMC2678823 Disease Relevance 0.51 Pain Relevance 0
Firstly, coloured dupplex ultrasonografy, and then carotid digital substraction anjiografy were performed to all patients undergoing CEA.
Localization (undergoing) of CEA
13) Confidence 0.55 Published 2009 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2678823 Disease Relevance 0.43 Pain Relevance 0.32
serves two roles in the CeA: (i) to reduce spontaneous baseline GABA release, and (ii) to mediate CRF- and ethanol-stimulated release of GABA.
Localization (release) of CeA associated with gaba and amygdala
14) Confidence 0.51 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.46 Pain Relevance 0.58
We selected 3, 6, and 17 ng/mL s-CEA as practical cutoff points, which highly discriminate between higher and lower risk groups with respect to survival.
Localization (selected) of CEA
15) Confidence 0.50 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782159 Disease Relevance 0.53 Pain Relevance 0
There now exists the highest level of evidence (AHA/ACC class I, level of evidence A) that there is clinical equipoise between CAS and CEA for patients at increased surgical risk for CEA.
Localization (equipoise) of CEA
16) Confidence 0.50 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948384 Disease Relevance 0.72 Pain Relevance 0
There now exists the highest level of evidence (AHA/ACC class I, level of evidence A) that there is clinical equipoise between CAS and CEA for patients at increased surgical risk for CEA.
Localization (equipoise) of CEA
17) Confidence 0.50 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948384 Disease Relevance 0.73 Pain Relevance 0
In HE sections, features common to xenografts of brain metastasis included: a) sharp boundary between tumor mass and surrounding normal brain tissue (Figure 4A and 4B); b) round and densely arranged tumor cells; c) abundant caryocinesia; d) abundant acid mucus secretion by tumor cells that were dyed blue by Alcian blue and red by PAS; e) positive immunostaining for CEA (Figure 5A and 5B).
Localization (secretion) of CEA in brain associated with cancer and metastasis
18) Confidence 0.45 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2907866 Disease Relevance 1.57 Pain Relevance 0.08
This means that CEA, although present in the tumor, is not always released in measurable amounts.
Neg (not) Localization (released) of CEA associated with cancer
19) Confidence 0.42 Published 1978 Journal Cancer Section Abstract Doc Link 361213 Disease Relevance 1.03 Pain Relevance 0.09
These results suggest that CA125, CA19-9, and CEA are synthesized and secreted by normal epithelial cells of central airways and/or respiratory glands and that these substances are not specific indicators of abnormal cellular activity.
Localization (secreted) of CEA in glands
20) Confidence 0.42 Published 1990 Journal Cancer Section Abstract Doc Link 2297641 Disease Relevance 0.23 Pain Relevance 0.09

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