INT213741

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 60
Total Number 74
Disease Relevance 44.24
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
retinas 8
endothelial cells 7
blood 4
pituitary 4
plasma 2
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 1035 99.84 Very High Very High Very High
metalloproteinase 81 99.76 Very High Very High Very High
anesthesia 95 98.08 Very High Very High Very High
imagery 528 97.88 Very High Very High Very High
Central nervous system 5 94.12 High High
corticosteroid 145 93.04 High High
Inflammatory response 25 91.44 High High
pain pelvic 15 90.12 High High
fibrosis 111 86.28 High High
Inflammation 175 84.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 2110 99.84 Very High Very High Very High
Diabetes Mellitus 1740 99.84 Very High Very High Very High
Endometriosis 1485 99.84 Very High Very High Very High
Glioma 290 99.84 Very High Very High Very High
Breast Cancer 40 99.72 Very High Very High Very High
Ganglion Cysts 53 98.28 Very High Very High Very High
Fibrosis 121 98.00 Very High Very High Very High
Hypoxia 211 97.96 Very High Very High Very High
Pituitary Cancer 129 97.64 Very High Very High Very High
Myocardial Infarction 483 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGFR-1 (Flt-1) and VEGFR-2 (KDR, /FLK-1) are expressed on the cell surface of most blood endothelial cells, whereas VEGFR-3 is largely restricted to the lymphatic endothelial cells.
Gene_expression (expressed) of KDR in blood
1) Confidence 0.75 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.46 Pain Relevance 0
In our model, we were able to demonstrate that the expression of VEGF and Flk-1 is enhanced in endometriotic lesions as compared with controls.
Gene_expression (expression) of Flk-1 associated with endometriosis
2) Confidence 0.68 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.93 Pain Relevance 0.35
To investigate the expression of VEGF and Flk-1 and MMP-9 in eutopic endometrium and in endometriotic lesions, RT-PCR was performed.
Spec (investigate) Gene_expression (expression) of Flk-1 in endometrium associated with endometriosis
3) Confidence 0.68 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.10 Pain Relevance 0
For detection of VEGF-A, FLK-1, and FLT-1, the sections were treated with antigen retrieval solution (Dako) at 90°C for 10 min, subsequently cooled to room temperature, and then quenched with H2O2 blocker.
Gene_expression (detection) of FLK-1
4) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0 Pain Relevance 0
Retinal protein expression of VEGF-A, FLK-1, and FLT-1.
Gene_expression (expression) of FLK-1
5) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.43 Pain Relevance 0
In our study, the direct relationship between the expression of FLK-1 and the vascular permeability/breakdown of the BRB was further investigated in the diabetic retina.
Gene_expression (expression) of FLK-1 in retina associated with diabetes mellitus
6) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.60 Pain Relevance 0
We also show that IVTA does not alter physiological VEGF-A, FLK-1, and FLT-1 levels in the normal retina.
Gene_expression (levels) of FLK-1 in retina
7) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.66 Pain Relevance 0.05
The expression of VEGF-A and its two receptors (FLK-1 and FLT-1) was found predominantly in the ganglion cell layer, inner nuclear layer, and outer plexiform layer of all four treatment groups.
Gene_expression (expression) of FLK-1 in inner nuclear layer associated with ganglion cysts
8) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.50 Pain Relevance 0
Immunohistochemical detection of retinal VEGF-A, FLK-1, FLT-1, and albumin.
Gene_expression (detection) of FLK-1
9) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0 Pain Relevance 0
The overexpression of VEGF-A and FLK-1 that was found in the diabetic retina in this study, in association with increased albumin leakage, supports the hypothesis that FLK-1 is another important permeability factor and regulator of BRB dysfunction in diabetes.
Gene_expression (overexpression) of FLK-1 in retina associated with diabetes mellitus
10) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.62 Pain Relevance 0
Peritoneal endometriotic lesions with high proliferative activity are also accompanied by high angiogenic activity, as reflected by higher expression of VEGF-A in stroma and glandular epithelium and VEGFR-2 in blood vessels [15].
Gene_expression (expression) of VEGFR-2 in epithelium associated with endometriosis
11) Confidence 0.59 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.33 Pain Relevance 0.11
To detect VEGF-A, FLT-1, or FLK-1 antigen, the chest cavity was opened following anesthesia as described above.
Gene_expression (detect) of FLK-1 in cavity associated with anesthesia
12) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.13 Pain Relevance 0.23
Vascular endothelial growth factor (VEGF) is a potent glial-derived stimulator of vascular remodeling in various tissues with both the VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1)-type receptors expressed by endothelial cells.
Gene_expression (expressed) of KDR in endothelial cells
13) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.44 Pain Relevance 0.22
In our recent study, we showed that the vascular density and the expression of VEGF and its receptor VEGFR-2 (Flk-1) are significantly higher in deeply infiltrating endometriosis affecting the ovary, bladder and mainly the rectosigmoid, compared with the eutopic endometrium [16].
Gene_expression (expression) of Flk-1 in ovary associated with endometriosis
14) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.34 Pain Relevance 0.09
In addition, Wang et al. (2005) [29] reported a higher Flk-1 expression in endometriosis lesions of the peritoneal and abdominal wall, which may have been associated with neovascularization.
Gene_expression (expression) of Flk-1 associated with endometriosis
15) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.89 Pain Relevance 0.23
The levels of VEGF, Flk-1 and MMP-9 mRNA transcripts in the endometriotic lesions were higher than in the eutopic endometrium (Fig. 3).


Gene_expression (levels) of Flk-1 in endometrium associated with endometriosis
16) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.68 Pain Relevance 0.18
Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases

Background

Gene_expression (expression) of VEGFR-2 associated with endometriosis, cancer, metalloproteinase and disease
17) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Title Doc Link PMC2826344 Disease Relevance 1.02 Pain Relevance 0.34
We have investigated the morphological characteristics of these lesions and the vascular density, VEGF and its receptor Flk-1 and MMP-9 expression, and activated macrophage distribution, using immunohistochemistry and RT-PCR.


Gene_expression (expression) of Flk-1 in macrophage
18) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2826344 Disease Relevance 0.99 Pain Relevance 0.31
In our recent study, we showed that the vascular density and the expression of VEGF and its receptor VEGFR-2 (Flk-1) are significantly higher in deeply infiltrating endometriosis affecting the ovary, bladder and mainly the rectosigmoid, compared with the eutopic endometrium [16].
Gene_expression (expression) of VEGFR-2 in ovary associated with endometriosis
19) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.34 Pain Relevance 0.09
In this study, we established a rat experimental model of peritoneal endometriosis, and we analyzed the vascular density and expression of VEGF and its receptor VEGFR-2 (Flk-1) and MMP-9, with the objective to evaluate the angiogenesis process and its implication in the establishment and growing of endometriosis.
Spec (analyzed) Gene_expression (expression) of VEGFR-2 associated with endometriosis
20) Confidence 0.53 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.82 Pain Relevance 0.30

General Comments

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