INT213758

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tfeb) DNA binding (Tfeb) cytoplasm (Tfeb)
Anatomy Link Frequency
bladder 1
Tfeb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 108 95.16 Very High Very High Very High
cytokine 13 91.72 High High
antagonist 3 70.56 Quite High
ketamine 2 25.04 Quite Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
interstitial cystitis 11 5.00 Very Low Very Low Very Low
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 40 96.80 Very High Very High Very High
INFLAMMATION 134 95.16 Very High Very High Very High
Cancer 28 84.16 Quite High
Immune System Diseases 1 81.28 Quite High
Dermatological Disease 1 77.44 Quite High
Apoptosis 4 70.12 Quite High
Microphthalmia 46 5.00 Very Low Very Low Very Low
Cystitis 17 5.00 Very Low Very Low Very Low
Bladder Cancer 13 5.00 Very Low Very Low Very Low
Interstitial Cystitis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The resulting TFEB binding values for each genomic region were also normalized for primer pair amplification efficiency using the Q-PCR values obtained with Input DNA (unprecipitated genomic DNA).
Regulation (values) of TFEB
1) Confidence 0.23 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.05 Pain Relevance 0
These results strongly suggested that TFEB, a member of the MiTF family of bHLH-Zip transcription factors, was the only TF commonly altered by PAR1-AP, PAR2-AP, and PAR4-AP and therefore, occupied the center of Venn diagram (Figure 2).


Regulation (altered) of TFEB
2) Confidence 0.23 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.20 Pain Relevance 0.07
In this network, TFEB was up-regulated and this gene encodes a transcriptional factor expressed in the urothelium and detrusor muscle that responds to bladder inflammation [22].
Regulation (regulated) of TFEB in bladder associated with inflammation and overactive bladder
3) Confidence 0.12 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.72 Pain Relevance 0.21

General Comments

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