INT213766

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 3.18
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
uterus 1
mast cell 1
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 77.68 Quite High
Inflammatory stimuli 3 52.40 Quite High
interstitial cystitis 4 38.32 Quite Low
agonist 1 33.52 Quite Low
Inflammatory response 7 25.80 Quite Low
substance P 3 20.88 Low Low
metalloproteinase 17 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
wide dynamic range 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 34 100.00 Very High Very High Very High
Mastocytosis 1 98.96 Very High Very High Very High
Stress 15 97.80 Very High Very High Very High
Experimental Melanoma 4 97.24 Very High Very High Very High
Melanoma 292 96.16 Very High Very High Very High
Adhesions 16 82.24 Quite High
Cancer 181 82.08 Quite High
INFLAMMATION 54 77.68 Quite High
Metastasis 52 58.76 Quite High
Cystitis 8 46.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, multiple factors in addition to MITF may be responsible for the differential expression of developmental genes associated with the invasive potential of metastatic melanoma cells.
Spec (may) Regulation (responsible) of MITF associated with melanoma
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.77 Pain Relevance 0
For example, MITF was shown to bind and transactivate the HIF1a promoter in mouse B16 melanoma cells [29], yet in our study HIF1a was inversely correlated with MITF expression, particularly in the invasive cell lines, suggesting de-regulated MITF and/or cAMP signalling in NZM cells, or that B16 cells may not be a good model of human metastatic melanoma.
Regulation (regulated) of MITF associated with melanoma and experimental melanoma
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.57 Pain Relevance 0
Several signals are known to modulate Mitf transactivation activity [39], [40].
Regulation (modulate) of Mitf associated with microphthalmia
3) Confidence 0.38 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.17 Pain Relevance 0
Each assay was repeated in three independent experiments resulting in 15 fields of view for each cell line. siRNA-mediated knockdown of MITF was performed in two randomly chosen Motif 2 cell lines (NZM06, NZM15) by using reverse transfection with Lipofectamine RNAiMAX (Invitrogen) and a pre-designed siRNA targeting MITF (Ambion) according to the manufacturer's instructions, with a final siRNA concentration of 5 nM.
Regulation (targeting) of MITF
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0 Pain Relevance 0
Thirty-five of the genes in our 96-gene invasion signature are known or predicted targets of MITF [18], and although experimentally confirmed MITF targets such as MLANA, RAB27A, and GPR143 corresponded closely with MITF expression in our data, some did not, suggesting a disconnect in MITF signalling for some MITF targets in certain melanomas.
Regulation (targets) of MITF associated with melanoma
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.58 Pain Relevance 0
Others have shown that mast cell tryptase and MiTF are highly sensitive and specific markers for mast cell disease [69].
Regulation (sensitive) of MiTF in mast cell associated with mastocytosis and microphthalmia
6) Confidence 0.18 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.59 Pain Relevance 0.10
When considering the targeting genes of differentially expressed miRNAs, the genes involved in metabolic process, response to stress and vasculogenesis are significantly enriched among the differentially expressed genes in both groups.
Regulation (targeting) of miRNAs associated with stress
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.35 Pain Relevance 0
Among the target genes of the up-regulated miRNAs predicted by either TargetScan or PITA, 63.93% of the target genes predicted was really down-regulated in our study, suggesting the target genes of up-regulated miRNAs during activation were significantly enriched.
Regulation (regula) of miRNAs
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Therefore, 44 genes (with repeat, 39 unique genes) were coherent target of up-regulated miRNAs in activated uterus. 76 genes (with repeats, 44 unique genes) were coherent target of down-regulated miRNAs.
Regulation (target) of miRNAs in uterus
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.15 Pain Relevance 0
Among the target genes of the up-regulated miRNAs predicted by either TargetScan or PITA, 63.93% of the target genes predicted is really down-regulated, suggesting that the target genes of significantly up-regulated miRNAs during activation are significantly enriched.
Regulation (regulated) of miRNAs
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Therefore, it is possible to use the comparative expression analysis of miRNAs and mRNAs to identify mRNA targets of miRNAs.
Regulation (targets) of miRNAs
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0

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