INT213769

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.96
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Spg21) nucleus (Spg21) biological_process (Spg21)
cytoplasm (Spg21)
Anatomy Link Frequency
Nerves 7
Mast cells 5
urinary bladder 1
basophils 1
gut 1
Spg21 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 741 100.00 Very High Very High Very High
cytokine 227 99.92 Very High Very High Very High
antagonist 51 99.92 Very High Very High Very High
unmyelinated 64 99.36 Very High Very High Very High
substance P 563 98.80 Very High Very High Very High
Serotonin 80 98.52 Very High Very High Very High
Calcitonin gene-related peptide 144 96.56 Very High Very High Very High
qutenza 64 95.04 Very High Very High Very High
Neuropeptide 432 94.84 High High
tolerance 16 90.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 684 100.00 Very High Very High Very High
Infection 96 98.80 Very High Very High Very High
Disease 92 98.64 Very High Very High Very High
Stress 208 98.34 Very High Very High Very High
Neurogenic Inflammation 128 98.16 Very High Very High Very High
Hypersensitivity 68 97.36 Very High Very High Very High
Injury 51 95.92 Very High Very High Very High
Microphthalmia 23 90.88 High High
Anaphylaxis 108 90.16 High High
Mastocytosis 1 90.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cells are strategically located for optimal interaction with the environment and for their putative functions in host defense [72].
Mast Binding (interaction) of in Mast cells
1) Confidence 0.03 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.91 Pain Relevance 0.36
Therefore, mast cells could trigger the recruitment of late-phase inflammation via IL-33-mediated recruitment of ST2-expressing basophils to the site of antigen exposure.
mast Binding (recruitment) of in basophils associated with inflammation
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.46 Pain Relevance 0.16
Mast cells are being increasingly recognized as critical cells in regulating a broad spectrum of immune responses, both protective and pathogenic.
Mast Binding (recognized) of in Mast cells
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.56 Pain Relevance 0.33
Structural studies show that mast cells associate with nerves in the lung.
mast Binding (associate) of in lung
4) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.55 Pain Relevance 0.49
Interestingly, capsaicin (which releases neuropeptides from nerves) applied to human skin induces the release of chymase within 6 hours and the induction of E-selectin in adjacent microvascular endothelium, events consistent with release of substance P from axons and subsequent stimulation of cytokine-mediated mast cell interaction with endothelial cells.
mast Binding (interaction) of in mast cell associated with qutenza, neuropeptide, cytokine and substance p
5) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.86 Pain Relevance 0.79
New findings will continue to increase our understanding of mast cell-nerve associations and their function in health and disease and will be followed by new therapeutic and diagnostic approaches.


mast Binding (associations) of in nerve associated with disease
6) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.45 Pain Relevance 0.20
The physiologic effects of psychological stress are often largely mediated by CRH, released either centrally or peripherally, and mast cell-nerve interactions are important components of this response [112].
mast Binding (interactions) of in nerve associated with stress
7) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.66 Pain Relevance 0.39
The classic mediators of inflammation are not alone in their ability to influence the interaction between mast cells and nerves.
mast Binding (interaction) of in mast cells associated with inflammation
8) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.31 Pain Relevance 0.64
Although there are several pathways by which immune cells interact with the nervous system, the focus in this review will be on the interaction between mast cells and nerves.



mast Binding (interaction) of in nerves
9) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Abstract Doc Link PMC2877069 Disease Relevance 0 Pain Relevance 0.04
Association of Mast Cells and Nerves
Mast Binding (Association) of in Nerves
10) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.37 Pain Relevance 0.26
Other than in the intestine, nerve and mast cell associations are found in rat trachea and peripheral lung tissue [9], skin [10], urinary bladder [11], brain [12], and several other tissues [13,14].
mast Binding (associations) of in urinary bladder
11) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.50 Pain Relevance 0.34
Unmyelinated axons especially were found to associate with mast cells as well as Langerhans' cells in primate as well as murine skin.
mast Binding (associate) of in skin associated with unmyelinated
12) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Abstract Doc Link PMC2877069 Disease Relevance 0 Pain Relevance 0.05
Mast cell-nerve association appears to function as a homeostatic unit in the regulation of gut physiology and in response to antigens [138].
Mast Binding (association) of in gut
13) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.48 Pain Relevance 0.60
Interaction of Mast Cells and Nerves
Mast Binding (Interaction) of in Nerves
14) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.20 Pain Relevance 0.26
Interaction of Mast Cells and Nerves in Tissues
Mast Binding (Interaction) of in Nerves
15) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.20 Pain Relevance 0.19
Furthermore, interactions between mast cells and the nervous system appear to be involved in UVB-mediated immune suppression.
mast Binding (interactions) of in nervous system
16) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.22 Pain Relevance 0.60
Interactions between mast cells and nerves have also been interpreted as important neuronal tissue repair mechanisms following injury [71,74].
mast Binding (Interactions) of in neuronal associated with injury
17) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.77 Pain Relevance 0.40
The classic mediators of inflammation are not alone in their ability to influence the interaction between mast cells and nerves.
mast Binding (interaction) of in nerves associated with inflammation
18) Confidence 0.00 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.31 Pain Relevance 0.64
Although there are several pathways by which immune cells interact with the nervous system, the focus in this review will be on the interaction between mast cells and nerves.



mast Binding (interaction) of in mast cells
19) Confidence 0.00 Published 2005 Journal Allergy Asthma Clin Immunol Section Abstract Doc Link PMC2877069 Disease Relevance 0 Pain Relevance 0.04

General Comments

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