INT21377

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.14
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GNRHR) signal transducer activity (GNRHR)
Anatomy Link Frequency
neuronal 1
brain 1
anterior pituitary 1
GNRHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 3 99.92 Very High Very High Very High
Neuropeptide 5 98.94 Very High Very High Very High
Serotonin 1 96.88 Very High Very High Very High
bDMF 1 91.28 High High
opiate 2 88.72 High High
gABA 5 69.44 Quite High
Opioid 1 68.96 Quite High
Neurotransmitter 4 54.36 Quite High
Action potential 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 74.40 Quite High
Obesity 6 67.04 Quite High
Stress 6 42.64 Quite Low
Body Weight 2 5.52 Low Low
Precocious Puberty 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Weight Gain 3 5.00 Very Low Very Low Very Low
Hypogonadotropic Hypogonadism 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overall role of dopamine in regulating the GnRH pulse generator in humans is not known because both facilitative effects of central dopamine and inhibitory effects of peripheral (extra blood-brain barrier) dopamine have been described.
Regulation (regulating) of GnRH pulse generator in brain associated with dopamine
1) Confidence 0.58 Published 1990 Journal Clin Obstet Gynecol Section Abstract Doc Link 2171822 Disease Relevance 0 Pain Relevance 0.34
On the other hand, investigation for GnRH receptor mutations revealed that genetic variation in GnRH1 and GnRHR is not likely to be a substantial modulator of pubertal timing in the general population [33].
Neg (not) Spec (likely) Regulation (likely) of GnRHR
2) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.07 Pain Relevance 0
Regulation of the gonadotropin-releasing hormone (GnRH) neuronal system: morphological aspects.
Regulation (Regulation) of gonadotropin-releasing hormone in neuronal
3) Confidence 0.25 Published 1989 Journal J. Steroid Biochem. Section Title Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.13
Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH (Gonadotropin-releasing hormone, also known as Luteinizing-Hormone-Releasing Hormone or LHRH), the latter responsible for the release of FSH and LH from the anterior pituitary.
Regulation (regulation) of Gonadotropin-releasing hormone in anterior pituitary associated with neuropeptide
4) Confidence 0.04 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2992060 Disease Relevance 0.07 Pain Relevance 0.12

General Comments

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