INT213772

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.50
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tfeb) DNA binding (Tfeb) cytoplasm (Tfeb)
Anatomy Link Frequency
mast cells 3
bladder 1
Tfeb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 215 99.20 Very High Very High Very High
cytokine 5 84.80 Quite High
Inflammatory mediators 5 81.52 Quite High
interstitial cystitis 20 51.36 Quite High
Inflammatory stimuli 15 38.96 Quite Low
Inflammatory response 35 5.00 Very Low Very Low Very Low
substance P 15 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 115 99.96 Very High Very High Very High
INFLAMMATION 270 99.20 Very High Very High Very High
Cystitis 40 91.68 High High
Adhesions 5 72.60 Quite High
Interstitial Cystitis 20 51.36 Quite High
Coronary Artery Disease 5 36.72 Quite Low
Mastocytosis 5 16.08 Low Low
Overactive Bladder 55 5.00 Very Low Very Low Very Low
Renal Cancer 15 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To the best of our knowledge, this is the first report describing TFEB expression in response to PAR activation in the bladder and suggest a unifying, mechanistic pathway of bladder inflammation as follows: we hypothesize that mast cells release tryptase resulting in increased PAR activation and, consequently, TFEB/MiTF activity.
Positive_regulation (activation) of TFEB in mast cells associated with inflammation and microphthalmia
1) Confidence 0.39 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.76 Pain Relevance 0.29
Our present findings further emphasize that products of mast cells such as tryptase inducing activation of PARs can lead to increased activity of transcription factors such as TFEB that play a fundamental role in mast cell survival.
Positive_regulation (increased) of TFEB in mast cell
2) Confidence 0.39 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.70 Pain Relevance 0.23
To the best of our knowledge, this is the first report describing TFEB expression in response to PAR activation in the bladder and suggest a unifying, mechanistic pathway of bladder inflammation as follows: we hypothesize that mast cells release tryptase resulting in increased PAR activation and, consequently, TFEB/MiTF activity.
Positive_regulation (increased) of TFEB in mast cells associated with inflammation and microphthalmia
3) Confidence 0.39 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.76 Pain Relevance 0.29
The findings that TFEB is downstream of activation of all PARs, makes this transcriptional factor a novel therapeutic target for the treatment of inflammatory disorders of the bladder.


Positive_regulation (activation) of TFEB in bladder associated with inflammation
4) Confidence 0.39 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.74 Pain Relevance 0.28
EMSA results confirmed the increased TFEB binding activity in C57BL/6 but not in Kitw/Kitw-v mice.


Positive_regulation (increased) of TFEB
5) Confidence 0.39 Published 2007 Journal BMC Immunol Section Abstract Doc Link PMC2000913 Disease Relevance 0.54 Pain Relevance 0.27

General Comments

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