INT213782

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Spg21) nucleus (Spg21) biological_process (Spg21)
cytoplasm (Spg21)
Anatomy Link Frequency
mast cell 3
Spg21 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 7 99.90 Very High Very High Very High
Central nervous system 8 99.74 Very High Very High Very High
Inflammation 123 96.96 Very High Very High Very High
cytokine 25 95.92 Very High Very High Very High
unmyelinated 8 83.16 Quite High
Serotonin 10 72.96 Quite High
substance P 73 38.04 Quite Low
agonist 7 24.88 Low Low
interstitial cystitis 6 23.72 Low Low
Inflammatory stimuli 3 11.32 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 124 99.70 Very High Very High Very High
Adhesions 1 90.88 High High
Disease 12 65.64 Quite High
Cystitis 8 64.04 Quite High
Anaphylaxis 8 63.28 Quite High
Hypersensitivity 8 62.64 Quite High
Microphthalmia 23 60.88 Quite High
Interstitial Cystitis 6 23.72 Low Low
Stress 26 12.08 Low Low
Neurogenic Inflammation 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another possibility is that inflammatory mediators can modulate the mast cell sensitivity to PAR-APs.
Regulation (modulate) of mast in mast cell associated with inflammatory mediators
1) Confidence 0.03 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.73 Pain Relevance 0.25
These data support the potential for intestinal mucosal mast cell regulation by the central nervous system and suggest modulation of mast cells without degranulation.
Regulation (regulation) of mast in mast cell associated with central nervous system
2) Confidence 0.00 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.34 Pain Relevance 0.20
These data support the potential for intestinal mucosal mast cell regulation by the central nervous system and suggest modulation of mast cells without degranulation.
Regulation (modulation) of mast in mast cell associated with central nervous system
3) Confidence 0.00 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.34 Pain Relevance 0.20

General Comments

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