INT213789

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.32
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
mast cell 2
platelet 1
bladder 1
stem cell 1
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 88 100.00 Very High Very High Very High
Inflammatory response 14 87.92 High High
substance P 6 64.16 Quite High
aspirin 4 63.28 Quite High
fibrosis 3 47.08 Quite Low
Paracetamol 5 42.64 Quite Low
agonist 2 38.64 Quite Low
Pain 11 32.40 Quite Low
positron emission tomography 15 18.32 Low Low
backache 1 11.68 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 110 100.00 Very High Very High Very High
Microphthalmia 46 98.28 Very High Very High Very High
Myelodysplastic Syndromes 62 96.84 Very High Very High Very High
Myeloid Leukemia 154 95.72 Very High Very High Very High
Myelofibrosis 29 95.68 Very High Very High Very High
Cystitis 16 94.24 High High
Apoptosis 6 92.84 High High
Mastocytosis 50 92.32 High High
Hyperplasia 2 91.80 High High
Systemic Mastocytosis 40 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In neoplastic mast cell lines, valine or tyrosine substitution for an aspartate in c-kit codon 816 results in constitutive phosphorylation and activation of KIT[6].
Phosphorylation (phosphorylation) of KIT in mast cell
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292130 Disease Relevance 0.62 Pain Relevance 0
Absence of PAR-induced bladder inflammation in c-kit-deficient mice
Phosphorylation (inflammation) of c-kit in bladder associated with inflammation
2) Confidence 0.53 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.73 Pain Relevance 0.26
C-KIT autophosphorylation, activation of mitogen activated protein (MAP) kinase and activation of Akt were all inhibited in a c-KIT expressing cell line.
Phosphorylation (autophosphorylation) of C-KIT
3) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.70 Pain Relevance 0
In addition, c-kit- and m-Csf-dependent MAPK phosphorylation transcriptionally activates both TFE3 and MiTF, which is necessary for mast cell developmental functions [54].
Phosphorylation (phosphorylation) of c-kit in mast cell associated with microphthalmia
4) Confidence 0.46 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.23 Pain Relevance 0.14
Nilotinib was also as effective as imatinib in inhibiting phosphorylation of c-kit in HMC-1(560) cells.
Phosphorylation (phosphorylation) of c-kit
5) Confidence 0.45 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.68 Pain Relevance 0
Based upon the potential for imatinib mesylate to inhibit the tyrosine kinase phosphorylation of c-Kit (the stem cell factor receptor essential for erythroid progenitor cell proliferation) imatinib mesylate was tested in a variety of trials for PV.
Phosphorylation (phosphorylation) of c-Kit in stem cell associated with myelodysplastic syndromes
6) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 0.90 Pain Relevance 0.03
Imatinib is a 2-phenylaminopyrimidin derivate (Figure 1) and was initially developed as a specific platelet-derived growth factor receptor (PDGFR) inhibitor, but was later found to inhibit autophosphorylation of Abl and c-Kit.
Phosphorylation (autophosphorylation) of c-Kit in platelet
7) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.46 Pain Relevance 0

General Comments

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