INT21379

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 1990
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 65
Total Number 69
Disease Relevance 15.64
Pain Relevance 27.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
nucleus 22
amygdala 8
hypothalamus 7
plasma 3
brain 3
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 135 100.00 Very High Very High Very High
Neuropeptide 27 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
orphanin 4 100.00 Very High Very High Very High
Nerve growth factor 3 100.00 Very High Very High Very High
withdrawal 116 99.92 Very High Very High Very High
Morphine 42 99.92 Very High Very High Very High
Enkephalin 74 99.80 Very High Very High Very High
Pain 22 99.80 Very High Very High Very High
fluoxetine 55 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 355 99.92 Very High Very High Very High
Cystitis 8 99.84 Very High Very High Very High
Urological Neuroanatomy 13 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 19 99.46 Very High Very High Very High
Depression 80 99.40 Very High Very High Very High
Adrenal Insufficiency 3 98.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 98.24 Very High Very High Very High
Aids-related Complex 24 98.16 Very High Very High Very High
Anxiety Disorder 40 97.76 Very High Very High Very High
Hypertension 3 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In-situ hybridization with synthetic oligonucleotide probes was used to determine the mRNA content of corticotrophin-releasing factor (CRF) and proenkephalin A mRNA in the paraventricular nucleus, and of pro-opiomelanocortin (POMC) mRNA in the anterior pituitary gland of male rats immediately after, and during recovery from, chronic high-dose prednisolone treatment.
Spec (determine) Transcription (content) of corticotrophin-releasing factor in gland
1) Confidence 0.72 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.07 Pain Relevance 0.07
In-situ hybridization with synthetic oligonucleotide probes was used to determine the mRNA content of corticotrophin-releasing factor (CRF) and proenkephalin A mRNA in the paraventricular nucleus, and of pro-opiomelanocortin (POMC) mRNA in the anterior pituitary gland of male rats immediately after, and during recovery from, chronic high-dose prednisolone treatment.
Spec (determine) Transcription (content) of CRF in gland
2) Confidence 0.72 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.07 Pain Relevance 0.07
We found that sustained hypovolemia evoked a brief episode of CRH gene transcription in ADX rats that occurred earlier than in intact rats.
Transcription (transcription) of CRH gene associated with pressure volume 2 under development
3) Confidence 0.71 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.40 Pain Relevance 0.04
Furthermore, there is evidence of enhanced CRF transcription, release, and neuronal activity after the administration of and withdrawal from several drugs of abuse, including cannabis, cocaine, ethanol, and morphine.
Transcription (transcription) of CRF in neuronal associated with cannabis, withdrawal, morphine and cocaine
4) Confidence 0.70 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17297634 Disease Relevance 0.46 Pain Relevance 0.49
We examined the effects of cyclophosphamide (CP)-induced cystitis on the expression of corticotropin-releasing hormone (CRH) mRNA in the paraventricular nucleus (PVN) and the serum levels of adrenocorticotropic hormone (ACTH) using in situ hybridization histochemistry and radioimmunoassay.
Transcription (expression) of corticotropin-releasing hormone in nucleus associated with cystitis
5) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.25 Pain Relevance 0.04
We examined the effects of cyclophosphamide (CP)-induced cystitis on the expression of corticotropin-releasing hormone (CRH) mRNA in the paraventricular nucleus (PVN) and the serum levels of adrenocorticotropic hormone (ACTH) using in situ hybridization histochemistry and radioimmunoassay.
Transcription (expression) of CRH in nucleus associated with cystitis
6) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.25 Pain Relevance 0.04
These results suggest that corticosterone affects CRH gene transcription in the PVHmpd using two mechanisms: first, inhibition, which probably uses type II glucocorticoid receptor-dependent mechanisms and contributes to classic negative feedback; and second, facilitation, which is seen at low plasma concentrations and maintains gene transcription in the presence of sustained stress, possibly using type I mechanisms.
Transcription (transcription) of CRH gene in plasma associated with stress
7) Confidence 0.70 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.30 Pain Relevance 0
This suggests that one reason why adrenal insufficiency severely compromises survival of sustained stress is that CRH gene transcription cannot be maintained without previous exposure to low levels of plasma corticosterone.
Transcription (transcription) of CRH gene in plasma associated with stress and adrenal insufficiency
8) Confidence 0.70 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.35 Pain Relevance 0
We have used in situ hybridization to investigate how basal levels of circulating corticosterone modulate CRH gene transcription in the neuroendocrine parvicellular part of the hypothalamic paraventricular nucleus (PVHmpd) during sustained hypovolemia.
Transcription (transcription) of CRH gene in nucleus associated with pressure volume 2 under development
9) Confidence 0.70 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.16 Pain Relevance 0
Concordant with this view is evidence of enhanced CRF transcription, release and activity following withdrawal from several drugs of abuse.
Transcription (transcription) of CRF associated with withdrawal
10) Confidence 0.69 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610870 Disease Relevance 0.53 Pain Relevance 0.53
c-fos and CRF receptor gene transcription in the brain of acetic acid-induced somato-visceral pain in rats.
Transcription (transcription) of CRF in brain associated with pain and visceral pain
11) Confidence 0.69 Published 2004 Journal Pain Section Title Doc Link 15288415 Disease Relevance 0.07 Pain Relevance 0.59
Levels of transcripts for mRNA for both CRF and POMC were markedly reduced after the treatment, but there was a rapid return to control values for CRF mRNA within 18 h of steroid withdrawal.
Transcription (transcripts) of CRF associated with withdrawal
12) Confidence 0.69 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.13 Pain Relevance 0.08
Interestingly, there was no increase of corticotrophin-releasing factor (CRF) mRNA expression in the PVN and central nucleus of the amygdala of Sprague-Dawley rats subjected to the AA treatment.
Transcription (expression) of corticotrophin-releasing factor in nucleus associated with amygdala
13) Confidence 0.68 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0.06 Pain Relevance 0.19
Interestingly, there was no increase of corticotrophin-releasing factor (CRF) mRNA expression in the PVN and central nucleus of the amygdala of Sprague-Dawley rats subjected to the AA treatment.
Transcription (expression) of CRF in nucleus associated with amygdala
14) Confidence 0.68 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0.06 Pain Relevance 0.19
We asked three questions: first, does corticotropin-releasing hormone (CRH) gene transcription occur in neuroendocrine neurones of the hypothalamic paraventricular nucleus (PVH) of ADX rats, and if so, how is it temporally organized; second, what is the expression pattern of the vasopressin and other genes known to be colocalized in these neuroendocrine neurones; third, if adrenocorticotropin hormone (ACTH) secretion occurs, what is its temporal profile?
Transcription (transcription) of corticotropin-releasing hormone in nucleus
15) Confidence 0.68 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.24 Pain Relevance 0.04
We asked three questions: first, does corticotropin-releasing hormone (CRH) gene transcription occur in neuroendocrine neurones of the hypothalamic paraventricular nucleus (PVH) of ADX rats, and if so, how is it temporally organized; second, what is the expression pattern of the vasopressin and other genes known to be colocalized in these neuroendocrine neurones; third, if adrenocorticotropin hormone (ACTH) secretion occurs, what is its temporal profile?
Transcription (transcription) of CRH in nucleus
16) Confidence 0.68 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.24 Pain Relevance 0.04
Although increased vasopressin gene transcription was not seen in intact hypovolemic rats, robust increases were measured throughout in ADX rats, suggesting that in the absence of corticosterone the vasopressin gene is transcribed preferentially to the CRH gene during sustained hypovolemia. c-fos and preproenkephalin mRNA profiles also exhibited earlier onsets compared to intact rats.
Transcription (transcribed) of CRH gene associated with pressure volume 2 under development
17) Confidence 0.68 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.40 Pain Relevance 0.04
The neurochemical identity of these activated neurons showed striking similarities between the BSTov and the CEAl; All IL-1beta-responsive cells were GABAergic, the majority of c-fos- positive cells expressed ENK mRNA (BSTov, 81%; CEAl, 94%), and some expressed NT mRNA (BSTov, 23%; CEAl, 22%), whereas very few expressed CRH mRNA (BSTov, 4%; CEAl, 1%).
Transcription (expressed) of CRH mRNA in CEAl associated with gabaergic, enkephalin and amygdala
18) Confidence 0.68 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464374 Disease Relevance 0 Pain Relevance 0.91
The effects of immobilization on the expression of immediate-early gene c-fos and nerve growth factor-inducible (NGFI)-B mRNAs, corticotropin-releasing factor (CRF) mRNA, CRF heteronuclear RNA (hnRNA), CRF receptor types 1 and 2alpha mRNA, and enkephalin hn/mRNA were investigated in the hypothalamic paraventricular nucleus of Wistar-Kyoto (WKY) rats and borderline hypertensive rats (BHRs).
Transcription (expression) of CRF in nerve associated with nerve growth factor, hypertension and enkephalin
19) Confidence 0.67 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9523573 Disease Relevance 0.24 Pain Relevance 0.28
Using this method, the ERbeta mRNA coexpressions with the novel opioid neuropeptide (orphanin FQ and its receptor ORL1) mRNA in addition to the previously reported neuropeptide (arginine vasopressin-AVP, oxytocin-OXY, corticotropin releasing hormone-CRH, enkephalin-ENK) mRNAs were assessed.
Transcription (coexpressions) of corticotropin releasing hormone associated with orphanin, neuropeptide, enkephalin and opioid
20) Confidence 0.67 Published 2003 Journal Anat. Embryol. Section Abstract Doc Link 12690447 Disease Relevance 0 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox