INT213793

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsb2) extracellular region (Tpsb2)
Anatomy Link Frequency
embryo 1
mast cells 1
Tpsb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 86 98.56 Very High Very High Very High
cytokine 2 79.64 Quite High
Inflammatory mediators 2 76.36 Quite High
agonist 2 72.36 Quite High
Inflammatory response 14 64.64 Quite High
substance P 6 59.72 Quite High
interstitial cystitis 8 5.00 Very Low Very Low Very Low
Inflammatory stimuli 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 46 99.34 Very High Very High Very High
INFLAMMATION 108 98.56 Very High Very High Very High
Adhesions 2 67.44 Quite High
Cystitis 16 40.60 Quite Low
Coronary Artery Disease 2 28.72 Quite Low
Mastocytosis 2 21.84 Low Low
Leukemia 2 16.12 Low Low
Renal Cancer 6 10.96 Low Low
Overactive Bladder 22 5.00 Very Low Very Low Very Low
Interstitial Cystitis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result of increased of MiTF activity in mast cells there is mMCP-6 and mMCP-7 synthesis, leading to additional signals for inflammation.
Gene_expression (synthesis) of mMCP-6 in mast cells associated with inflammation and microphthalmia
1) Confidence 0.02 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.75 Pain Relevance 0.28
Mast cell proteases mcpt-5 (chymase), and the tryptases mcpt-6 and mcpt-7 are all expressed during the development of the mouse embryo [63].
Gene_expression (expressed) of tryptases mcpt-6 in embryo
2) Confidence 0.01 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.27 Pain Relevance 0.17

General Comments

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