INT213794

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.56
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
mast cell 1
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 91.68 High High
Inflammation 43 72.32 Quite High
substance P 3 67.92 Quite High
agonist 1 42.40 Quite Low
Central nervous system 12 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
interstitial cystitis 4 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 56 100.00 Very High Very High Very High
INFLAMMATION 54 91.68 High High
Leukemia 4 75.36 Quite High
Renal Cancer 3 70.20 Quite High
Genetic Translocation 1 61.76 Quite High
Skin Cancer 21 48.72 Quite Low
Nevus 3 45.92 Quite Low
Apoptosis 15 39.92 Quite Low
Death 33 5.00 Very Low Very Low Very Low
Toxicity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, c-kit- and m-Csf-dependent MAPK phosphorylation transcriptionally activates both TFE3 and MiTF, which is necessary for mast cell developmental functions [54].
Phosphorylation (phosphorylation) of MiTF in mast cell associated with microphthalmia
1) Confidence 0.42 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.22 Pain Relevance 0.15
Activity of this pathway results in phosphorylation of Microphthalmia transcription factor (Mitf); phosphorylation of Mitf regulates its activity and stability [7], [8].
Phosphorylation (phosphorylation) of Mitf associated with microphthalmia
2) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.44 Pain Relevance 0
Activity of this pathway results in phosphorylation of Microphthalmia transcription factor (Mitf); phosphorylation of Mitf regulates its activity and stability [7], [8].
Phosphorylation (phosphorylation) of Microphthalmia transcription factor associated with microphthalmia
3) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.44 Pain Relevance 0
Activity of this pathway results in phosphorylation of Microphthalmia transcription factor (Mitf); phosphorylation of Mitf regulates its activity and stability [7], [8].
Phosphorylation (phosphorylation) of Mitf associated with microphthalmia
4) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.45 Pain Relevance 0

General Comments

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