INT213797

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Kit, Tfe3) cytoplasm (Kit, Tfe3) pigmentation (Kit)
cell differentiation (Kit) extracellular space (Kit) plasma membrane (Kit)
Anatomy Link Frequency
mast cell 1
Kit (Mus musculus)
Tfe3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 90.96 High High
Inflammation 43 71.60 Quite High
substance P 3 67.20 Quite High
agonist 1 41.68 Quite Low
interstitial cystitis 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 23 99.80 Very High Very High Very High
INFLAMMATION 54 90.96 High High
Leukemia 1 76.64 Quite High
Renal Cancer 3 71.48 Quite High
Genetic Translocation 1 63.04 Quite High
Overactive Bladder 11 5.00 Very Low Very Low Very Low
Cystitis 8 5.00 Very Low Very Low Very Low
Interstitial Cystitis 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Bladder Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, c-kit- and m-Csf-dependent MAPK phosphorylation transcriptionally activates both TFE3 and MiTF, which is necessary for mast cell developmental functions [54].
c-kit Positive_regulation (activates) of TFE3 in mast cell associated with microphthalmia
1) Confidence 0.28 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.24 Pain Relevance 0.14

General Comments

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