INT213809

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.61
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl3) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) plasma membrane (F2rl3) signal transducer activity (F2rl3)
Anatomy Link Frequency
urinary bladder 1
neurons 1
mast cell 1
F2 (Mus musculus)
F2rl3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 67 99.56 Very High Very High Very High
agonist 29 96.64 Very High Very High Very High
bradykinin 8 78.16 Quite High
Inflammatory mediators 7 75.36 Quite High
qutenza 28 62.16 Quite High
Pain 14 61.44 Quite High
Inflammatory response 7 52.80 Quite High
imagery 14 52.16 Quite High
substance P 13 48.40 Quite Low
Nerve growth factor 28 11.28 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 80 99.56 Very High Very High Very High
Injury 9 92.00 High High
Pain 14 61.44 Quite High
Microphthalmia 23 58.68 Quite High
Nociception 42 50.00 Quite Low
Mastocytosis 1 47.12 Quite Low
Coagulation Disorder 4 18.88 Low Low
Overactive Bladder 11 5.00 Very Low Very Low Very Low
Cystitis 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
thrombin Positive_regulation (activator) of PAR4 in urinary bladder
1) Confidence 0.12 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.32 Pain Relevance 0.11
PAR1, PAR3, and PAR4 are activated by thrombin, reviewed in [5,6], while PAR2 is not activated by thrombin but is activated by trypsin and mast cell tryptase [7-9].
thrombin Positive_regulation (activated) of PAR4 in mast cell
2) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.22 Pain Relevance 0.09
Combined with the results in Fig. 3 (above) these results suggest that PAR4 receptors in DRG neurons are functionally activated by thrombin but that PAR3 receptors are not.


thrombin Positive_regulation (activated) of PAR4 in neurons
3) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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