INT213812

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Sh2b2, Tfeb) nucleus (Tfeb) plasma membrane (Sh2b2)
DNA binding (Tfeb) signal transducer activity (Sh2b2)
Sh2b2 (Mus musculus)
Tfeb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 99.26 Very High Very High Very High
Inflammation 43 79.76 Quite High
interstitial cystitis 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 54 99.08 Very High Very High Very High
Overactive Bladder 11 59.20 Quite High
Microphthalmia 23 10.16 Low Low
Cystitis 8 5.00 Very Low Very Low Very Low
Interstitial Cystitis 4 5.00 Very Low Very Low Very Low
Renal Cancer 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Bladder Cancer 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kitw/Kitw-v mice failed to mount an inflammatory response to PAR1-AP, and EMSA confirmed that TFEB is upregulated by all PAR-APs in wild type mice but not in Kitw/Kitw-v mice.
APs Positive_regulation (upregulated) of TFEB associated with inflammatory response
1) Confidence 0.44 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.45 Pain Relevance 0.20

General Comments

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