INT213886

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 16.79
Pain Relevance 6.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL23R)
Anatomy Link Frequency
bowel 2
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 348 100.00 Very High Very High Very High
Crohn's disease 196 100.00 Very High Very High Very High
Inflammation 178 99.76 Very High Very High Very High
psoriasis 80 98.44 Very High Very High Very High
rheumatoid arthritis 86 97.64 Very High Very High Very High
Multiple sclerosis 54 93.68 High High
spondylitis 16 84.88 Quite High
cytokine 35 84.00 Quite High
Arthritis 23 82.16 Quite High
Central nervous system 1 52.28 Quite High
Disease Link Frequency Relevance Heat
Disease 554 100.00 Very High Very High Very High
Ankylosing Spondylitis 252 100.00 Very High Very High Very High
Inflammatory Bowel Disease 179 99.76 Very High Very High Very High
Low Back Pain 112 99.28 Very High Very High Very High
Psoriasis 99 98.44 Very High Very High Very High
Systemic Lupus Erythematosus 14 98.32 Very High Very High Very High
Diabetes Mellitus 71 97.92 Very High Very High Very High
Rheumatoid Arthritis 93 97.64 Very High Very High Very High
Infection 8 95.52 Very High Very High Very High
Congenital Anomalies 3 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association with IL12B is of particular interest given the associations of IL23R and STAT3 with AS.
IL23R Binding (associations) of associated with spinal inflammation
1) Confidence 0.46 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.92 Pain Relevance 0.29
Thus far, only the gene IL23R (associated with AS) has also been found to be associated with inflammatory bowel disease (IBD) and psoriasis, although the three conditions commonly occur in the same patients, and are co-familial.
IL23R Binding (associated) of in bowel associated with psoriasis, spinal inflammation, inflammatory bowel disease and inflammation
2) Confidence 0.46 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 2.58 Pain Relevance 1.01
It also further confirms association for IL23R and detects suggestive association with another 4 loci.
IL23R Binding (association) of
3) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 0.93 Pain Relevance 0.54
It also further confirms association for IL23R and detects suggestive association with another 4 loci.
IL23R Binding (association) of
4) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 1.00 Pain Relevance 0.55
In a recent study, IL23R association with AS was confirmed with a peak signal within the gene at rs11209026 (P?
IL23R Binding (association) of associated with spinal inflammation
5) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.73 Pain Relevance 0.45
One of the 1st AS risk loci identified, IL23R, is also associated with both forms of IBD (ulcerative colitis and Crohn's disease) as well as psoriasis.
IL23R Binding (associated) of associated with psoriasis, spinal inflammation, inflammatory bowel disease, crohn's disease and disease
6) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 1.54 Pain Relevance 0.51
We did not find any association of CD not only with Arg381Gln, but also two other more frequent variants of IL23R.
IL23R Neg (not) Binding (association) of associated with crohn's disease
7) Confidence 0.34 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 1.23 Pain Relevance 0.57
For instance, while association of the IL23R gene with inflammatory bowel disease, psoriasis and ankylosing spondylitis [25] has been shown before, only recently has its involvement also been linked to MS [40].
IL23R Binding (association) of in bowel associated with spinal inflammation, psoriasis, multiple sclerosis and inflammation
8) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 1.61 Pain Relevance 0.91
As mentioned before, IL23R variants have been shown to be associated with both CD and AS [2], [4].
IL23R Binding (associated) of associated with spinal inflammation and crohn's disease
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970560 Disease Relevance 2.39 Pain Relevance 1.12
Two previously established associations, namely with the MHC and IL23R loci, were confirmed.
IL23R Binding (associations) of
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970560 Disease Relevance 1.15 Pain Relevance 0.50
Genetic evidence for an (auto)immune basis of psoriasis is provided by the well-known association of the disease with the HLA-Cw6 gene [3] and the recently discovered associations with IL12B and IL23R [4], [5].
IL23R Binding (associations) of associated with psoriasis and disease
11) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.07 Pain Relevance 0.21
An association between SNP's in IL23R (IL-23 receptor ?
IL23R Binding (receptor) of
12) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2001184 Disease Relevance 1.64 Pain Relevance 0.28

General Comments

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