INT213894

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 2
interneurons 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 15 100.00 Very High Very High Very High
alcohol 37 99.64 Very High Very High Very High
GABAergic 31 99.48 Very High Very High Very High
Cannabinoid 101 94.28 High High
gABA 36 93.84 High High
Inflammation 1 83.00 Quite High
Pain 4 80.04 Quite High
antagonist 35 73.64 Quite High
Endocannabinoid 55 72.20 Quite High
Central nervous system 7 58.36 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 6 98.16 Very High Very High Very High
INFLAMMATION 1 83.00 Quite High
Neurodegenerative Disease 83 80.28 Quite High
Pain 4 80.04 Quite High
Recurrence 19 77.92 Quite High
Drug Dependence 17 69.84 Quite High
Convulsion 3 24.64 Low Low
Alcohol Addiction 2 19.00 Low Low
Catalepsy 14 18.44 Low Low
Hypothermia 3 17.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CB1 mRNA expression is induced by activity
Positive_regulation (induced) of Transcription (expression) of CB1
1) Confidence 0.69 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.22 Pain Relevance 0
These researchers also reported that at least in the strain of rats bred for its ethanol preference, the Marchigian-Sardinian alcohol-preferring rats, CB1 cannabinoid receptor mRNA expression was increased in brain areas relevant for processing reward and reward-associated behavior, suggesting that alterations in the function of the CB1 receptor system may be linked to genetic vulnerability to alcohol misuse (Cippitelli et al 2005).
Positive_regulation (increased) of Transcription (expression) of CB1 in brain associated with cannabinoid receptor, sprains and strains and alcohol
2) Confidence 0.66 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656312 Disease Relevance 0.42 Pain Relevance 0.62
In particular, CB1 protein and mRNA are present at very high levels in cortical GABAergic interneurons (those that release ?
Positive_regulation (levels) of Transcription (present) of CB1 protein in interneurons associated with gabaergic
3) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.16 Pain Relevance 0.72

General Comments

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