INT213895

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) signal transducer activity (Cnr1) cytoplasm (Mastl)
signal transduction (Cnr1) mitosis (Mastl) plasma membrane (Cnr1)
Anatomy Link Frequency
neuronal 2
body 2
Mastl (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 60 99.84 Very High Very High Very High
Cannabinoid 84 94.32 High High
antagonist 6 90.04 High High
Autonomic response 2 86.56 High High
Analgesic 22 80.64 Quite High
dopamine receptor 24 76.36 Quite High
Central nervous system 12 58.44 Quite High
Cannabinoid receptor 12 54.44 Quite High
Dopamine 8 44.88 Quite Low
Pain 8 25.00 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 4 98.16 Very High Very High Very High
Body Weight 4 94.32 High High
Targeted Disruption 4 66.12 Quite High
Pain 8 25.00 Low Low
Catalepsy 28 5.00 Very Low Very Low Very Low
Hypothermia 6 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
Hypoalagesia 4 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that several important pharmacological actions of THC do not depend on functional expression of CB1 on GABAergic interneurons, but on other neuronal populations, and pave the way to a refined interpretation of the pharmacological effects of cannabinoids on neuronal functions.


THC Neg (not) Regulation (depend) of Gene_expression (expression) of CB1 in neuronal associated with cannabinoid and gabaergic
1) Confidence 0.17 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2001214 Disease Relevance 0.07 Pain Relevance 0.40
To verify that the “tetrad” effects of THC fully depend on CB1 expression under our experimental conditions and in our strain of CB1-null mutants, we first performed a dose-response (0, 1, 3, and 10 mg THC/kg mouse body weight [mg/kg]) study of these effects of THC in mice and then used the dose of 10 mg/kg on CB1?
THC Regulation (depend) of Gene_expression (expression) of CB1 in body associated with body weight and sprains and strains
2) Confidence 0.09 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.19 Pain Relevance 0.26

General Comments

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