INT2139

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Context Info
Confidence 0.43
First Reported 1978
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 55
Total Number 56
Disease Relevance 43.59
Pain Relevance 9.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
plasma 1
liver 1
neurons 1
14.1 1
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 96 100.00 Very High Very High Very High
analgesia 16 100.00 Very High Very High Very High
Pain 28 99.98 Very High Very High Very High
Enkephalin 33 99.40 Very High Very High Very High
pain pelvic 1 97.96 Very High Very High Very High
Morphine 3 97.48 Very High Very High Very High
Chronic pancreatitis 19 97.28 Very High Very High Very High
palliative 24 96.64 Very High Very High Very High
abdominal pain 13 94.24 High High
imagery 19 94.20 High High
Disease Link Frequency Relevance Heat
Cancer 453 100.00 Very High Very High Very High
Anxiety Disorder 61 100.00 Very High Very High Very High
Pain 30 99.98 Very High Very High Very High
Disease Progression 117 99.96 Very High Very High Very High
Pressure And Volume Under Development 6 99.90 Very High Very High Very High
Colon Cancer 96 99.84 Very High Very High Very High
Hepatotoxicity 23 99.84 Very High Very High Very High
Metastasis 196 99.76 Very High Very High Very High
Pleural Effusion 2 99.76 Very High Very High Very High
Breast Cancer 31 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical relief of bone pain was observed in 7 of 23 patients with a decline in carcinoembryonic antigen (CEA) tumor makers in 8 patients.
Negative_regulation (decline) of CEA associated with pain and cancer
1) Confidence 0.43 Published 1992 Journal Perspect. Biol. Med. Section Abstract Doc Link 1501996 Disease Relevance 2.46 Pain Relevance 0.35
CEA was decreased within normal range from a maximum of 9.3.
Negative_regulation (decreased) of CEA
2) Confidence 0.43 Published 2006 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 17212112 Disease Relevance 1.12 Pain Relevance 0.17
Usually a decrease of CEA values is observed, lasting for some months.
Negative_regulation (decrease) of CEA
3) Confidence 0.43 Published 1996 Journal Ann Ital Chir Section Abstract Doc Link 9214271 Disease Relevance 0.61 Pain Relevance 0.12
After 2 sessions of the chemotherapy, the gluteal pain decreased, and after 3 sessions, CEA level was confirmed and the patient's QOL began to improve.
Negative_regulation (decreased) of CEA associated with pain
4) Confidence 0.43 Published 2003 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 14619530 Disease Relevance 0.61 Pain Relevance 0.19
In conclusion, chronic social isolation stress exacerbated conditioning memory in SAM mice, probably through a glucocorticoid-mediated decrease in neural activation in the CeA.
Negative_regulation (decrease) of CeA in CeA associated with stress
5) Confidence 0.42 Published 2006 Journal Brain Res. Section Abstract Doc Link 16332359 Disease Relevance 1.03 Pain Relevance 0.23
In order to test the effectiveness of CA19-9, KM01, unabsorbed CEA (carcinoembryonic antigen) and absorbed CEA by immunoperoxidase staining, we evaluated the staining distribution, intensity, and cellular localization in pancreatic cancer.
Negative_regulation (effectiveness) of CEA associated with pancreatic cancer
6) Confidence 0.41 Published 1990 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 1689141 Disease Relevance 0.65 Pain Relevance 0.27
In order to test the effectiveness of CA19-9, KM01, unabsorbed CEA (carcinoembryonic antigen) and absorbed CEA by immunoperoxidase staining, we evaluated the staining distribution, intensity, and cellular localization in pancreatic cancer.
Negative_regulation (effectiveness) of CEA associated with pancreatic cancer
7) Confidence 0.41 Published 1990 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 1689141 Disease Relevance 0.73 Pain Relevance 0.28
The CEA level decreased as T3, T4 level and malnutrition were improved by administration of a massive digestive enzyme preparation.
Negative_regulation (decreased) of CEA associated with appetite loss
8) Confidence 0.37 Published 1991 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 1885126 Disease Relevance 0.92 Pain Relevance 0.10
In some patients, CEA levels of peripheral blood were decreased and tumor necrosis was proved histologically.
Negative_regulation (decreased) of CEA in blood associated with necrosis and cancer
9) Confidence 0.37 Published 1988 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 3382204 Disease Relevance 0.85 Pain Relevance 0.19
CONCLUSIONS: Shunt insertion was the only parameter correlated with cognitive decline on the first day after CEA.
Negative_regulation (decline) of CEA
10) Confidence 0.37 Published 2010 Journal J Neurosurg Anesthesiol Section Body Doc Link 20479673 Disease Relevance 0 Pain Relevance 0
A failure of the CEA to return to normal levels after surgical resection is indicative of inadequate resection of occult systemic disease.
Negative_regulation (failure) of CEA associated with disease
11) Confidence 0.37 Published 2005 Journal Cancer Invest. Section Abstract Doc Link 16100946 Disease Relevance 0.95 Pain Relevance 0
Increasing CEA levels always signaled disease progression, decreasing CEA levels were found to be associated with improvement.
Negative_regulation (decreasing) of CEA associated with disease progression
12) Confidence 0.36 Published 1980 Journal Oncodev. Biol. Med. Section Abstract Doc Link 7279701 Disease Relevance 0.51 Pain Relevance 0.09
By contrast, a recent study showed that adrenalectomy decreased corticotropin-releasing factor-LI in the CeA and BNST [43], suggesting that the BNST and CeA are a part of an adrenal steroid-sensitive extrahypothalamic circuit and regulate the fear and anxiety of PTSD-like symptoms.
Negative_regulation (decreased) of CeA associated with post-traumatic stress disorder, anxiety disorder and amygdala
13) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2867948 Disease Relevance 1.47 Pain Relevance 0.80
In order to evaluate the response to radiotherapy symptomatic relief, CEA levels, decrease of tumor volume measured by CT analysis were correlated with the FDG-uptake.
Negative_regulation (decrease) of CEA associated with cancer
14) Confidence 0.35 Published 1992 Journal Strahlenther Onkol Section Abstract Doc Link 1574769 Disease Relevance 0.50 Pain Relevance 0.15
However, in CeA neurons of HET mice, the previously characterized ethanol-induced increase of GABAA-IPSPs was abolished.
Negative_regulation (abolished) of CeA in neurons associated with amygdala
15) Confidence 0.33 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.15 Pain Relevance 0.38
The tumor marker carcinoembryonic antigen (CEA) level decreased after treatment.
Negative_regulation (decreased) of CEA associated with cancer
16) Confidence 0.32 Published 1992 Journal Acta Med. Okayama Section Abstract Doc Link 1485536 Disease Relevance 0.61 Pain Relevance 0.10
There was also a significant (P = 0.002, Wilcoxon test) decrease in values of both serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9), from 7.6 +/- 1.3 ng/mL and 875.7 +/- 104.8 U/mL to 3.5 +/- 0.7 ng/mL and 65.3 +/- 14.1 U/mL respectively.
Negative_regulation (decrease) of CEA in 14.1
17) Confidence 0.32 Published 2002 Journal Eur J Cancer Care (Engl) Section Abstract Doc Link 12099945 Disease Relevance 0.91 Pain Relevance 0.17
In the BLA and CEA, 'high-anxiety' mice also displayed increased FRA/ENK after TMT exposure and LD testing.
Negative_regulation (displayed) of CEA associated with anxiety disorder and enkephalin
18) Confidence 0.30 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.54 Pain Relevance 0.93
After operation the serum CEA level was decreased immediately but it was gradually increased once again.
Negative_regulation (decreased) of CEA
19) Confidence 0.30 Published 1996 Journal Kyobu Geka Section Abstract Doc Link 8828337 Disease Relevance 0.52 Pain Relevance 0.08
50 patients with primary breast cancer were studied to determine the CEA and HCG contents in their tumor cells before any treatment was initiated.
Spec (determine) Negative_regulation (determine) of CEA associated with cancer and breast cancer
20) Confidence 0.29 Published 1978 Journal Cancer Section Abstract Doc Link 361213 Disease Relevance 0.74 Pain Relevance 0

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