INT213913

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOA3) small molecule metabolic process (NCOA3) Golgi apparatus (NCOA3)
nucleolus (NCOA3) nucleus (NCOA3) transferase activity, transferring acyl groups (NCOA3)
Anatomy Link Frequency
MCF-7 2
intermediary 1
NCOA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 99.30 Very High Very High Very High
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 207 99.76 Very High Very High Very High
Cancer 133 84.92 Quite High
Apoptosis 7 57.88 Quite High
Disease 30 26.64 Quite Low
Noninfiltrating Intraductal Carcinoma 2 24.64 Low Low
Advanced Or Metastatic Breast Cancer 24 5.00 Very Low Very Low Very Low
Recurrence 15 5.00 Very Low Very Low Very Low
Metastasis 12 5.00 Very Low Very Low Very Low
Carcinoma 7 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Shou et al. [4] reported that tamoxifen behaves as an agonist in MCF-7 breast cancer cells that express high levels of the coactivator AIB1 (src3) and HER2, resulting in de novo resistance.
Gene_expression (express) of AIB1 in MCF-7 associated with breast cancer and agonist
1) Confidence 0.50 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.34 Pain Relevance 0.05
Shou et al. [4] reported that tamoxifen behaves as an agonist in MCF-7 breast cancer cells that express high levels of the coactivator AIB1 (src3) and HER2, resulting in de novo resistance.
Gene_expression (express) of src3 in MCF-7 associated with breast cancer and agonist
2) Confidence 0.50 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.34 Pain Relevance 0.05
Parallel observations have also been made with the AIB-1 (amplified in breast cancer 1; SRC-3) protein, regarding both sensitization of ER transactivation and growth factor signal transduction.59 AIB1 is an ER coregulatory protein that together with other co-activators, like transcription intermediary factor 2 (TIF2) and nuclear receptor co-repressor (NCoR), is implicated in the estrogen signaling pathway and estrogen- regulated tumor progression.
Gene_expression (made) of AIB-1 in intermediary associated with cancer and breast cancer
3) Confidence 0.13 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.43 Pain Relevance 0

General Comments

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