INT213915

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERBB2) signal transduction (ERBB2) plasma membrane (ERBB2)
nucleus (ERBB2) cytoplasm (ERBB2)
ERBB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 51.32 Quite High
Inflammation 15 50.00 Quite Low
COX-2 inhibitor 1 48.72 Quite Low
cytokine 20 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 38 98.48 Very High Very High Very High
Hepatocellular Cancer 76 96.36 Very High Very High Very High
Breast Cancer 42 83.76 Quite High
Apoptosis 6 79.68 Quite High
Liver Cancer 11 57.60 Quite High
INFLAMMATION 17 51.08 Quite High
Advanced Or Metastatic Breast Cancer 10 50.88 Quite High
Hepatitis C Virus Infection 72 50.00 Quite Low
Cirrhosis 28 44.00 Quite Low
Stress 4 38.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In MCF-7Ca xenografts, combined treatment with fulvestrant and letrozole prevented increases in HER2 and activation of MAPK and inhibited tumor growth [49].
Negative_regulation (prevented) of Positive_regulation (increases) of HER2 associated with cancer
1) Confidence 0.41 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.35 Pain Relevance 0
Finally, the combination of 9-cis-retinoic acid (9cRA) plus trastuzumab resulted to inhibit the activation of HER2 and its downstream signaling pathways, subsequently inhibiting the phosphorylation of RXR alpha and the growth of HCC cells [76].


Negative_regulation (inhibit) of Positive_regulation (activation) of HER2 associated with hepatocellular cancer
2) Confidence 0.08 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.74 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox